Peginterferon with or without ribavirin has minimal effect on quality of life, behavioral/emotional, and cognitive outcomes in children
Department of Quantitative Health Sciences
Hepatitis C; Polyethylene Glycols; Interferon Alfa-2a; Ribavirin; Child; Adolescent
Biostatistics | Epidemiology | Health Services Research | Pediatrics | Virus Diseases
The aim of this study was to prospectively assess the quality of life (QOL), behavioral/emotional functioning, and cognitive status of children undergoing treatment for hepatitis C virus (HCV) infection. In all, 114 children (5 to 18 years old) enrolled in a multisite randomized clinical trial (Peds-C) to evaluate peginterferon alpha 2a (PEG 2a) with ribavirin (RV) or with placebo (PL) completed several standardized measures prior to treatment and at 24 weeks, 48 weeks, 6 months following treatment, and at two annual follow-up visits. After 24 weeks of treatment, mean physical QOL scores declined significantly for both groups from baseline to 24 weeks of treatment (F = 5.8, P = 0.004), although scores remained in the average range. There were no significant time or group effects for behavioral/emotional or cognitive functioning. Three children (5%) in the PEG 2a + RV group and no children in the PEG 2a + PL group had a clinically significant increase in depression symptoms. For those children who received 48 weeks of treatment, there were no significant time or group effects on any of the outcome measures (P > 0.05). A majority of children in both the PEG 2a + RV and PEG 2a + PL groups experienced no clinically significant change in physical QOL, behavioral adjustment, depression, or cognitive functioning during or after treatment.
Conclusion: Overall QOL and psychosocial functioning are not deleteriously impacted by PEG 2a + RV or PL treatment of children with HCV. (HEPATOLOGY 2011;).
DOI of Published Version
Hepatology. 2011 May;53(5):1468-75. doi: 10.1002/hep.24248. Link to article on publisher's site
Hepatology (Baltimore, Md.)
Rodrigue, James R.; Balistreri, William; Haber, Barbara; Jonas, Maureen M.; Mohan, Parvathi; Molleston, Jean P.; Murray, Karen F.; Narkewicz, Michael R.; Rosenthal, Philip; Smith, Lesley J.; Lobritto, Steven J.; Schwarz, Kathleen B.; Robuck, Patricia R.; Barton, Bruce A.; and Gonzalez-Perez, Regino P., "Peginterferon with or without ribavirin has minimal effect on quality of life, behavioral/emotional, and cognitive outcomes in children" (2011). Quantitative Health Sciences Publications and Presentations. 974.