Alcohol consumption, binge drinking, and early coronary calcification: findings from the Coronary Artery Risk Development in Young Adults (CARDIA) Study
Authors
Pletcher, Mark J.Varosy, Paul
Kiefe, Catarina I.
Lewis, Cora E.
Sidney, Stephen
Hulley, Stephen B.
UMass Chan Affiliations
Department of Quantitative Health SciencesDocument Type
Journal ArticlePublication Date
2005-02-19Keywords
AdultAfrican Continental Ancestry Group
Alcohol Drinking
Alcoholic Intoxication
Calcinosis
Chi-Square Distribution
Coronary Artery Disease
European Continental Ancestry Group
Female
Follow-Up Studies
Humans
Logistic Models
Longitudinal Studies
Male
Middle Aged
Prevalence
Risk Factors
Bioinformatics
Biostatistics
Epidemiology
Health Services Research
Metadata
Show full item recordAbstract
It is unclear to what extent the apparently beneficial cardiovascular effects of moderate alcohol consumption are mediated by protection against atherosclerosis. Alcohol consumption, coronary heart disease risk factors, and coronary calcification (a marker of atherosclerosis) were measured during 15 years of follow-up in the Coronary Artery Risk Development in Young Adults (CARDIA) Study (1985-2001). Among 3,037 participants aged 33-45 years after follow-up (55% women, 45% Black), the prevalence of coronary calcification was 8% for consumption of 0 drinks/week (n = 1,435), 9% for 1-6 drinks/week (n = 1,023), 13% for 7-13 drinks/week (n = 341), and 19% for > or = 14 drinks/week (n = 238) (p < 0.001 for trend). Calcification was also more common among binge drinkers (odds ratio = 2.1, 95% confidence interval: 1.6, 2.7). These associations persisted after adjustment for potential confounders (age, gender/ethnicity, income, physical activity, family history, body mass index, smoking) and intermediary factors (lipids, blood pressure, glucose, C-reactive protein, and fibrinogen). Stratification showed the dose-response relation most clearly in Black men; only heavier alcohol consumption (> or = 14 drinks/week) was associated with coronary calcification in other race/sex subgroups. These surprising findings suggest the presence of proatherogenic effects of alcohol in young adults, especially Black men, which may counterbalance high density lipoprotein cholesterol elevation and other possible benefits of alcohol consumption.Source
Am J Epidemiol. 2005 Mar 1;161(5):423-33. Link to article on publisher's siteDOI
10.1093/aje/kwi062Permanent Link to this Item
http://hdl.handle.net/20.500.14038/47451PubMed ID
15718478Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1093/aje/kwi062