A questionnaire to assess the generic and disease-specific health outcomes of patients with chronic hepatitis C

UMMS Affiliation

Department of Quantitative Health Sciences

Publication Date


Document Type



Adult; Cross-Sectional Studies; Female; *Health Status; Hepatitis C, Chronic; Humans; Male; Multivariate Analysis; *Psychometrics; *Questionnaires; Reproducibility of Results; Treatment Outcome


Biostatistics | Epidemiology | Health Services Research


A 69-item questionnaire measuring generic functioning and well-being and disease-specific health outcomes was developed and tested using the pre-treatment data from patients with chronic hepatitis C (CHC) participating in two randomized trials of interferon alpha-2b (n = 157). The questionnaire included all eight scales from the SF-36 and measures of nine other generic and disease-specific health concepts. Psychometric tests confirmed the assumptions underlying the construction and scoring of all generic and disease-specific scales. Cross-sectional tests of 'known groups' validity showed that CHC patients scored worse on the generic scales than patients with other chronic conditions and worse than a healthy general population. The generic and disease-specific scale scores were lower in the presence of physical findings of CHC, as hypothesized, but only the physical functioning and bodily pain scales were linked to cirrhosis or extreme alanine aminotransferase (ALT) ratios. This instrument will be useful in studies of health outcome among patients with CHC, a condition whose health burden appears to have been underestimated in studies to date.

DOI of Published Version



Qual Life Res. 1998 Jan;7(1):39-55. Link to article on publisher's site

Journal/Book/Conference Title

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation

PubMed ID


Related Resources

Link to Article in PubMed