UMMS Affiliation

Department of Quantitative Health Sciences; Department of Pediatrics

Publication Date


Document Type



Adolescent; Burkitt Lymphoma; Case-Control Studies; Child; Child, Preschool; *Endemic Diseases; *Family Characteristics; Female; Housing; Humans; Kenya; Male; Odds Ratio; Risk Factors


Biostatistics | Epidemiology | Health Services Research | Immunology and Infectious Disease | Pediatrics


Endemic Burkitt's lymphoma (eBL) has been linked to Epstein-Barr virus and holoendemic Plasmodium falciparum malaria. These co-infections, however, are insufficient to explain the non-random occurrence of Endemic Burkitt's lymphoma within Equatorial Africa. To explore whether this distribution could be explained by household characteristics and family environment, we conducted a case-control study using 41 hospitalized incident endemic Burkitt's lymphoma cases and 91 healthy controls identified through a population-based multistage cluster-sampling scheme in Nyanza Province, Kenya. In a multivariate analysis, odds ratios associated with having one, two, and three or more younger siblings compared with none were 0.28 (90% CI: 0.09, 0.83), 0.59 (90% CI: 0.16, 2.23) and 0.15 (90% CI: 0.03, 0.67) respectively, suggesting that children with endemic Burkitt's lymphoma were more likely than controls to be last-born. Children with endemic Burkitt's lymphoma were also more likely to live in non-monogamous families (OR=3.12, 90% CI:1.19, 8.17) and to have at least one deceased parent (OR=3.38, 90% CI: 1.18, 9.64). Household characteristics, especially sibship relationships, may contribute to endemic Burkitt's lymphoma and therefore warrant further study.

Rights and Permissions

Copyright © 2008 by The American Society of Tropical Medicine and Hygiene.


Am J Trop Med Hyg. 2008 Feb;78(2):338-43. Link to article on publisher's site

Journal/Book/Conference Title

The American journal of tropical medicine and hygiene

PubMed ID


Related Resources

Link to Article in PubMed



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