Department of Quantitative Health Sciences; Department of Pediatrics
Adolescent; Adult; Age Distribution; Child; Child, Preschool; Epstein-Barr Virus Infections; Herpesvirus 4, Human; Humans; Infant; Kenya; Malaria; United States; *Viral Load
Biostatistics | Epidemiology | Health Services Research | Immunology and Infectious Disease | Pediatrics
Perennial and intense malaria transmission (holoendemic malaria) and Epstein-Barr virus (EBV) infection are 2 cofactors in the pathogenesis of endemic Burkitt lymphoma (eBL). In the present study, we compared EBV loads in children living in 2 regions of Kenya with differing malaria transmission intensities: Kisumu District, where malaria transmission is holoendemic, and Nandi District, where malaria transmission is sporadic. For comparison, blood samples were also obtained from US adults, Kenyan adults, and patients with eBL. Extraction of DNA from blood and quantification by polymerase chain reaction give an EBV load estimate that reflects the number of EBV-infected B cells. We observed a significant linear trend in mean EBV load, with the lowest EBV load detected in US adults and increasing EBV loads detected in Kenyan adults, Nandi children, Kisumu children, and patients with eBL, respectively. In addition, EBV loads were significantly higher in Kisumu children 1-4 years of age than in Nandi children of the same age. Our results support the hypothesis that repeated malaria infections in very young children modulate the persistence of EBV and increase the risk for the development of eBL.
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© 2005 by the Infectious Diseases Society of America.
DOI of Published Version
J Infect Dis. 2005 Apr 15;191(8):1233-8. Epub 2005 Mar 9. Link to article on publisher's site
The Journal of infectious diseases
Moormann, Ann M.; Chelimo, Kiprotich; Sumba, Peter Odada; Lutzke, Mary L.; Ploutz-Snyder, Robert; Newton, Duane; Kazura, James W.; and Rochford, Rosemary A., "Exposure to holoendemic malaria results in elevated Epstein-Barr virus loads in children" (2005). Quantitative Health Sciences Publications and Presentations. 390.