Department of Quantitative Health Sciences; Department of Pediatrics
Antigens, CD14; Antigens, CD4; Female; Fetus; Fluorescent Antibody Technique, Direct; HIV Infections; Humans; Immunohistochemistry; Macrophages; Malaria; Placenta; Pregnancy; Pregnancy Complications, Parasitic; RNA, Messenger; Receptors, CCR5; Receptors, Chemokine; Transcriptional Activation
Biostatistics | Epidemiology | Health Services Research | Immunology and Infectious Disease
Malaria and human immunodeficiency virus (HIV) coinfections are common in pregnant women in sub-Saharan Africa. The current study shows that placentas of malaria-infected women contain 3 times as much CC chemokine receptor 5 (CCR5) RNA as placentas of women without malaria. By immunohistochemistry, CCR5(+) maternal macrophages were seen in placentas from malaria-infected women but not in placentas from malaria-uninfected women. In addition, CCR5 also was found on fetal Hofbauer cells in placentas from both groups. Thus, malaria infections increase the potential reservoir for HIV in the placenta by increasing the number of HIV target cells.
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© 2001 by the Infectious Diseases Society of America.
DOI of Published Version
J Infect Dis. 2001 Mar 15;183(6):967-72. Epub 2001 Feb 9. Link to article on publisher's site
The Journal of infectious diseases
Tkachuk, Ariana N.; Moormann, Ann M.; Poore, Judy A.; Rochford, Rosemary A.; Chensue, Stephen W.; Mwapasa, Victor; and Meshnick, Steven R., "Malaria enhances expression of CC chemokine receptor 5 on placental macrophages" (2001). Quantitative Health Sciences Publications and Presentations. 383.