Department of Quantitative Health Sciences; Department of Pediatrics
Cytokines; Female; Fetal Growth Retardation; HIV-1; Hemeproteins; Humans; Immunohistochemistry; Infant, Newborn; Malaria, Falciparum; Obstetric Labor, Premature; Placenta; Pregnancy; Pregnancy Complications, Parasitic; Pregnancy Outcome; RNA, Messenger; RNA, Viral; Reverse Transcriptase Polymerase Chain Reaction
Biostatistics | Epidemiology | Health Services Research | Immunology and Infectious Disease
Malaria infections during pregnancy can lead to the delivery of low-birth-weight infants. In this study, cytokine mRNA was measured in placentas from 23 malaria-infected and 21 uninfected primigravid women who had delivered in Mangochi, Malawi, a region with a high rate of transmission of falciparum malaria. Significantly increased expression of interleukin (IL)-1beta, IL-8, and tumor necrosis factor (TNF)-alpha and decreased expression of IL-6 and transforming growth factor-beta1 were found in malaria-infected compared with uninfected placentas. TNF-alpha and IL-8 were produced by maternally derived hemozoin-laden placental macrophages. Increased TNF-alpha expression was associated with increased placental hemozoin concentrations. Increased TNF-alpha or IL-8 expression in the placenta was associated with intrauterine growth retardation but not with preterm delivery. The results suggest that malaria infections induce a potentially harmful proinflammatory response in the placenta.
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© 1999 by the Infectious Diseases Society of America.
DOI of Published Version
J Infect Dis. 1999 Dec;180(6):1987-93. Link to article on publisher's site
The Journal of infectious diseases
Moormann, Ann M.; Sullivan, Amy D.; Rochford, Rosemary A.; Chensue, Stephen W.; Bock, Paul J.; Nyirenda, Thomas; and Meshnick, Steven R., "Malaria and pregnancy: placental cytokine expression and its relationship to intrauterine growth retardation" (1999). Quantitative Health Sciences Publications and Presentations. 382.