Malaria and pregnancy: placental cytokine expression and its relationship to intrauterine growth retardation
Authors
Moormann, Ann M.Sullivan, Amy D.
Rochford, Rosemary A.
Chensue, Stephen W.
Bock, Paul J.
Nyirenda, Thomas
Meshnick, Steven R.
Document Type
Journal ArticlePublication Date
1999-11-24Keywords
CytokinesFemale
Fetal Growth Retardation
HIV-1
Hemeproteins
Humans
Immunohistochemistry
Infant, Newborn
Malaria, Falciparum
Obstetric Labor, Premature
Placenta
Pregnancy
Pregnancy Complications, Parasitic
Pregnancy Outcome
RNA, Messenger
RNA, Viral
Reverse Transcriptase Polymerase Chain Reaction
Biostatistics
Epidemiology
Health Services Research
Immunology and Infectious Disease
Metadata
Show full item recordAbstract
Malaria infections during pregnancy can lead to the delivery of low-birth-weight infants. In this study, cytokine mRNA was measured in placentas from 23 malaria-infected and 21 uninfected primigravid women who had delivered in Mangochi, Malawi, a region with a high rate of transmission of falciparum malaria. Significantly increased expression of interleukin (IL)-1beta, IL-8, and tumor necrosis factor (TNF)-alpha and decreased expression of IL-6 and transforming growth factor-beta1 were found in malaria-infected compared with uninfected placentas. TNF-alpha and IL-8 were produced by maternally derived hemozoin-laden placental macrophages. Increased TNF-alpha expression was associated with increased placental hemozoin concentrations. Increased TNF-alpha or IL-8 expression in the placenta was associated with intrauterine growth retardation but not with preterm delivery. The results suggest that malaria infections induce a potentially harmful proinflammatory response in the placenta.Source
J Infect Dis. 1999 Dec;180(6):1987-93. Link to article on publisher's siteDOI
10.1086/315135Permanent Link to this Item
http://hdl.handle.net/20.500.14038/47238PubMed ID
10558956Related Resources
Link to Article in PubMedRights
© 1999 by the Infectious Diseases Society of America.ae974a485f413a2113503eed53cd6c53
10.1086/315135