Incident diabetes in relation to weight patterns during middle age
UMass Chan Affiliations
Department of Quantitative Health SciencesDocument Type
Journal ArticlePublication Date
2010-01-30Keywords
AdultBody Mass Index
Body Weight
Cohort Studies
Diabetes Mellitus, Type 2
Female
Humans
Incidence
Male
Middle Aged
Obesity
Risk Factors
Weight Gain
Weight Loss
Bioinformatics
Biostatistics
Epidemiology
Health Services Research
Metadata
Show full item recordAbstract
The authors examined the association between weight patterns during middle age and incident type 2 diabetes mellitus using a subset (n = 1,476) of the Framingham Heart Study original cohort limited-access data set (1948-2003). Participants diagnosed with diabetes before age 50 years were excluded. A functional principal components analysis of body mass index from age 40 years to age 50 years was used to define weight patterns in terms of overall weight status (normal weight, overweight, or obese), weight change (weight loss, stable weight, or weight gain), and weight cycling. Overall overweight and obesity were associated with higher rates of diabetes (for overall overweight, crude hazard ratio (HR) = 3.2, 95% confidence interval (CI): 2.3, 4.6; for overall obesity, crude HR = 8.8, 95% CI: 6.0, 12.8). Weight cycling was also associated with higher rates of diabetes (crude HR = 1.6, 95% CI: 1.2, 2.1). Neither weight loss nor weight gain was associated with incident diabetes. After adjustment for overall weight status, weight cycling was no longer associated with higher rates of diabetes. This study underscores the importance of obesity in diabetes risk and the importance of preventing the development of overweight and obesity earlier in life.Source
Am J Epidemiol. 2010 Mar 1;171(5):550-6. Epub 2010 Jan 28. Link to article on publisher's siteDOI
10.1093/aje/kwp433Permanent Link to this Item
http://hdl.handle.net/20.500.14038/47225PubMed ID
20110286Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1093/aje/kwp433