Clinical features, treatment practices, and hospital and long-term outcomes of older patients hospitalized with decompensated heart failure: The Worcester Heart Failure Study
Department of Medicine, Division of Cardiovascular Medicine; Department of Medicine, Division of Geriatric Medicine; Department of Emergency Medicine
Acute Disease; Age Factors; Aged; Aged, 80 and over; Body Mass Index; Cardiovascular Agents; Comorbidity; Drug Therapy, Combination; Female; Follow-Up Studies; Heart Failure; Hospital Mortality; *Hospitalization; Humans; Life Style; Male; Massachusetts; Multivariate Analysis; Odds Ratio; Prognosis; Retrospective Studies; Survival Rate
Bioinformatics | Biostatistics | Epidemiology | Health Services Research
OBJECTIVES: To examine age-specific differences in clinical presentation, receipt of therapeutic practices and lifestyle recommendations, and hospital and long-term survival in patients hospitalized for acute heart failure HF.
DESIGN: Population-based study.
SETTING: The Worcester Heart Failure Study, a population-based study of residents of the a large Central New England metropolitan area hospitalized for decompensated HF at 11 greater-Worcester medical centers.
PARTICIPANTS: Four thousand five hundred thirty-four patients hospitalized for decompensated HF during 1995 and 2000.
MEASUREMENTS: Medical records were reviewed for demographic, clinical, and treatment characteristics and hospital survival status. Long-term follow-up of discharged hospital patients was conducted through 2005. Patients were compared according to four age groups (<65, 65-74, 75-84, and > or =85).
RESULTS: Mean age was 76; 24.0% were aged 85 and older. Patients aged 75 and older were more likely to be female and to have multiple comorbidities, a lower body mass index at the time of hospitalization, and higher ejection fraction findings. Older patients were significantly more likely to receive symptom-modifying medications and less likely to receive disease-modifying medications than younger patients. Older age was directly associated with higher in-hospital, 30-day, and 1-year death rates in crude and multivariable-adjusted analyses.
CONCLUSION: The results of this community-wide study suggest that clinical, treatment, and prognostic factors differ according to age in patients hospitalized for decompensated HF. These high-risk patients warrant special attention in future studies to improve their management and long-term survival.
DOI of Published Version
J Am Geriatr Soc. 2009 Sep;57(9):1587-94. Epub 2009 Aug 13. Link to article on publisher's site
Journal of the American Geriatrics Society
Saczynski, Jane S.; Darling, Chad E.; Spencer, Frederick A.; Lessard, Darleen M.; Gore, Joel M.; and Goldberg, Robert J., "Clinical features, treatment practices, and hospital and long-term outcomes of older patients hospitalized with decompensated heart failure: The Worcester Heart Failure Study" (2009). Quantitative Health Sciences Publications and Presentations. 358.