Duration of the QT interval and total and cardiovascular mortality in healthy persons (The Framingham Heart Study experience)

UMMS Affiliation

Department of Medicine, Division of Cardiovascular Medicine

Publication Date

January 1991

Document Type



Adult; Cohort Studies; Coronary Disease; Death, Sudden; *Electrocardiography; Female; Follow-Up Studies; Heart Rate; Humans; Male; Massachusetts; Middle Aged; Prospective Studies; Regression Analysis; Risk Factors; Time Factors


Biostatistics | Epidemiology | Health Services Research


The baseline electrocardiograms of 5,125 original subjects of the Framingham Heart Study were measured to examine the relation of the QT interval corrected for heart rate (QTc) to risk of total mortality, sudden cardiac death, and death due to coronary artery disease over a 30-year follow-up period. Quintiles of QTc (seconds) less than or equal to 0.36, 0.36 to 0.38, 0.39 to 0.40, 0.41 to 0.43 and greater than or equal to 0.44 were studied in relation to these outcomes. There were no significant differences in the risk of total mortality, sudden cardiac death or death due to coronary artery disease according to QTc. A similar lack of significant association between QTc and these 3 outcomes was observed among all persons studied and in the 2 sexes after using a multiple regression analysis to control for several potentially confounding characteristics including age, gender, cigarette smoking, serum total cholesterol, systolic systemic blood pressure and Framingham relative weight. The results of this study fail to demonstrate an association between baseline QTc and overall mortality, and deaths due to sudden cardiac events or coronary artery disease in a large population-based cohort of essentially healthy persons in whom pathologic forms of QTc prolongation are uncommon.


Am J Cardiol. 1991 Jan 1;67(1):55-8.

Journal/Book/Conference Title

The American journal of cardiology

PubMed ID


Related Resources

Link to Article in PubMed

This document is currently not available here.