Title

Association between risk of obstructive sleep apnea and cognitive performance, frailty, and quality of life among older adults with atrial fibrillation

UMMS Affiliation

Division of Cardiovascular Medicine, Department of Medicine; Department of Population and Quantitative Health Sciences

Publication Date

2021-08-26

Document Type

Article

Disciplines

Cardiovascular Diseases | Geriatrics | Sleep Medicine

Abstract

STUDY OBJECTIVES: Geriatric impairments and obstructive sleep apnea (OSA) are prevalent among older patients with atrial fibrillation (AF). Little is known about the association between OSA and geriatric impairments including frailty, cognitive performance, and AF-related quality of life. The objective of this study was to examine the associations of OSA with frailty, cognitive performance, and AF-related quality of life among older adults with AF.

METHODS: Data from the Systemic Assessment of Geriatrics Elements-AF study were used which included AF participants 65 years and older and with a CHA2DS2-VASc > /=2. The STOP-BANG questionnaire was used to assess the risk of OSA. Multivariable logistic regression models were used to examine the association between risk of OSA and geriatric impairments, adjusting for sociodemographic, geriatric, and clinical characteristics.

RESULTS: A total of 970 participants (mean age 75 years; 51% male) were studied. Of the 680 participants without a medical history of OSA, 26% (n=179) of participants had a low risk of OSA, 53% (n=360) had an intermediate risk, and 21% (n=141) had a high risk for OSA. Compared to those with low risk of OSA, participants with an intermediate or high risk of OSA were more likely to be frail (adjusted odds ratio [aOR]= 1.67, 95% confidence interval [CI]: 1.08-2.56; aOR= 3.00, 95% CI: 1.69-5.32, respectively) in the fully adjusted models.

CONCLUSIONS: Our findings identify a group of patients at high risk who would benefit from early screening for OSA. Future longitudinal studies are needed to assess the effect of OSA treatment on frailty, physical functioning, and QoL among patients with AF.

Keywords

AF-related quality of life, atrial fibrillation, cognitive performance, frailty, obstructive sleep apnea

DOI of Published Version

10.5664/jcsm.9622

Source

Mehawej J, Saczynski JS, Kiefe CI, Abu HO, Tisminetzky M, Wang W, Bamgbade BA, Ding E, Lessard D, Otabil EM, Saleeba C, Goldberg RJ, McManus DD. Association between risk of obstructive sleep apnea and cognitive performance, frailty, and quality of life among older adults with atrial fibrillation. J Clin Sleep Med. 2021 Aug 26. doi: 10.5664/jcsm.9622. Epub ahead of print. PMID: 34432629. Link to article on publisher's site

Journal/Book/Conference Title

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

PubMed ID

34432629

Comments

This article is based on a previously available thesis: https://doi.org/10.13028/tq2g-pj40.

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