Title
Association between risk of obstructive sleep apnea and cognitive performance, frailty, and quality of life among older adults with atrial fibrillation
UMMS Affiliation
Division of Cardiovascular Medicine, Department of Medicine; Department of Population and Quantitative Health Sciences
Publication Date
2021-08-26
Document Type
Article
Disciplines
Cardiovascular Diseases | Geriatrics | Sleep Medicine
Abstract
STUDY OBJECTIVES: Geriatric impairments and obstructive sleep apnea (OSA) are prevalent among older patients with atrial fibrillation (AF). Little is known about the association between OSA and geriatric impairments including frailty, cognitive performance, and AF-related quality of life. The objective of this study was to examine the associations of OSA with frailty, cognitive performance, and AF-related quality of life among older adults with AF.
METHODS: Data from the Systemic Assessment of Geriatrics Elements-AF study were used which included AF participants 65 years and older and with a CHA2DS2-VASc > /=2. The STOP-BANG questionnaire was used to assess the risk of OSA. Multivariable logistic regression models were used to examine the association between risk of OSA and geriatric impairments, adjusting for sociodemographic, geriatric, and clinical characteristics.
RESULTS: A total of 970 participants (mean age 75 years; 51% male) were studied. Of the 680 participants without a medical history of OSA, 26% (n=179) of participants had a low risk of OSA, 53% (n=360) had an intermediate risk, and 21% (n=141) had a high risk for OSA. Compared to those with low risk of OSA, participants with an intermediate or high risk of OSA were more likely to be frail (adjusted odds ratio [aOR]= 1.67, 95% confidence interval [CI]: 1.08-2.56; aOR= 3.00, 95% CI: 1.69-5.32, respectively) in the fully adjusted models.
CONCLUSIONS: Our findings identify a group of patients at high risk who would benefit from early screening for OSA. Future longitudinal studies are needed to assess the effect of OSA treatment on frailty, physical functioning, and QoL among patients with AF.
Keywords
AF-related quality of life, atrial fibrillation, cognitive performance, frailty, obstructive sleep apnea
DOI of Published Version
10.5664/jcsm.9622
Source
Mehawej J, Saczynski JS, Kiefe CI, Abu HO, Tisminetzky M, Wang W, Bamgbade BA, Ding E, Lessard D, Otabil EM, Saleeba C, Goldberg RJ, McManus DD. Association between risk of obstructive sleep apnea and cognitive performance, frailty, and quality of life among older adults with atrial fibrillation. J Clin Sleep Med. 2021 Aug 26. doi: 10.5664/jcsm.9622. Epub ahead of print. PMID: 34432629. Link to article on publisher's site
Journal/Book/Conference Title
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
PubMed ID
34432629
Related Resources
Repository Citation
Mehawej J, Saczynski JS, Kiefe CI, Abu HO, Tisminetzky M, Wang W, Bamgbade BA, Ding EY, Lessard DM, Otabil EM, Saleeba C, Goldberg RJ, McManus DD. (2021). Association between risk of obstructive sleep apnea and cognitive performance, frailty, and quality of life among older adults with atrial fibrillation. Population and Quantitative Health Sciences Publications. https://doi.org/10.5664/jcsm.9622. Retrieved from https://escholarship.umassmed.edu/qhs_pp/1435
Comments
This article is based on a previously available thesis: https://doi.org/10.13028/tq2g-pj40.