Department of Quantitative Health Sciences
Epidemiology | Hematology | Hemic and Lymphatic Diseases | Mental and Social Health | Neoplasms | Oncology | Psychiatry and Psychology
The purpose of this study was to determine whether there is an increased risk of suicide in European Hodgkin Lymphoma (HL) patients compared to the general European population. European HL patients enrolled in the German Hodgkin Study Group (GHSG) HD7 through HD15 studies were analyzed and standardized mortality ratio (SMR) was calculated using suicide mortality rates for the general European population. Case-control analysis was performed to identify characteristics associated with risk of death by suicide. Among 12,202 European HL patients observed for 94,972 person-years, 19 suicides (17 males and 2 females) were identified resulting in a SMR 1.63 (95% CI: 1.01-2.50, p = 0.046). The only characteristic associated with a statistically significant increased risk of suicide was male sex with an odds ratio (OR) 8.42 (95% CI = 1.04-67.85; p = 0.046) on multivariate analysis. These findings were confirmed in an independently analyzed Surveillance, Epidemiology, and End Results Program (SEER) validation dataset. European HL patients have a significantly increased incidence of suicide compared to the general European population. Male HL patients have a greater than 8-fold increased risk of suicide compared to female HL patients. Further study of social risk factors associated with an increased risk of suicide in HL patients is needed.
European, German Hodgkin Study Group, Hodgkin lymphoma, Male, Suicide
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Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the European Hematology Association. This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
DOI of Published Version
Hemasphere. 2019 Feb 22;3(2):e183. doi: 10.1097/HS9.0000000000000183. eCollection 2019 Apr. Link to article on publisher's site
Kim AI, Goergen H, Engert A, LaCasce AS, Maranda LS, Barton BA, Borchmann S. (2019). Suicide in European Hodgkin Lymphoma Patients. Population and Quantitative Health Sciences Publications. https://doi.org/10.1097/HS9.0000000000000183. Retrieved from https://escholarship.umassmed.edu/qhs_pp/1319
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.