Title

Adjuvant Use and the Intensification of Pharmacologic Management for Pain in Nursing Home Residents with Cancer: Data from a US National Database

UMMS Affiliation

Division of Epidemiology of Chronic Diseases and Vulnerable Populations, Department of Quantitative Health Sciences

Publication Date

2019-06-01

Document Type

Article

Disciplines

Clinical Epidemiology | Epidemiology | Geriatrics | Health Services Research | Medical Pharmacology | Neoplasms | Pain Management | Pharmaceutical Preparations | Therapeutics

Abstract

OBJECTIVES: Our objective was to describe the prevalence of adjuvants to opioid therapy and changes in these agents for pharmacologic management in nursing home residents with cancer.

METHODS: We included Medicare beneficiaries with cancer and documented opioid use at nursing home admission in 2011-2013 (N = 3268). The Minimum Data Set 3.0 provided information on sociodemographic and clinical characteristics. Part D claims provided information on opioid and adjuvant use during the 7 days after admission and 90 days later. Proportions of changes in these agents were estimated. Separate logistic models estimated associations between resident characteristics and (1) use of adjuvants at admission and (2) intensification of pharmacologic management at 90 days.

RESULTS: Nearly 20% of patients received adjuvants to opioids at admission, with gabapentin the most common adjuvant (34.4%). After 90 days, approximately 25% had maintained or intensified pharmacologic management. While advanced age ( > /= 85 vs. 65-74 years, adjusted odds ratio [aOR] 0.80; 95% confidence interval [CI] 0.63-1.02) and comorbidities, including dementia (aOR 0.65; 95% CI 0.53-0.82) and depression (aOR 1.55; 95% CI 1.29-1.87), were associated with adjuvant use at admission, worse cognitive impairment (severe vs. no/mild, aOR 0.80; 95% CI 0.64-0.99) and presence of more severe pain (moderate/severe vs. no pain, aOR 1.60; 95% CI 1.26-2.03) were associated with intensification of drug regimen.

CONCLUSION: Given aging-related changes and the presence of comorbid conditions in older adults, safety studies of these practices are warranted.

DOI of Published Version

10.1007/s40266-019-00650-3

Source

Drugs Aging. 2019 Jun;36(6):549-557. doi: 10.1007/s40266-019-00650-3. Link to article on publisher's site

Journal/Book/Conference Title

Drugs and aging

PubMed ID

30924097

Related Resources

Link to Article in PubMed

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