Patterns of comorbidity in older adults with heart failure: the Cardiovascular Research Network PRESERVE study

UMMS Affiliation

Department of Quantitative Health Sciences; Meyers Primary Care Institute; Department of Medicine, Division of Cardiovascular Medicine; Department of Medicine, Division of Geriatric Medicine;

Publication Date


Document Type



Adult; Aged; Aged, 80 and over; Comorbidity; Cross-Sectional Studies; Digestive System Diseases; Female; Follow-Up Studies; Heart Failure; History, Ancient; Humans; Male; Mental Disorders; Middle Aged; Neoplasms; Retrospective Studies; Stroke Volume; United States; Young Adult


Bioinformatics | Biostatistics | Cardiology | Cardiovascular Diseases | Epidemiology | Health Services Research


OBJECTIVES: To examine whether the total burden of comorbidity and pattern of co-occurring conditions varies in individuals with heart failure (HF) with preserved left ventricular ejection fraction (LVEF) (HF-P) or HF with reduced LVEF (HF-R). DESIGN: Cross-sectional cohort study.

SETTING: Four participating health plans within the National Heart, Lung, and Blood Institute-sponsored Cardiovascular Research Network.

PARTICIPANTS: All members aged 65 and older with HF based on hospital discharge and ambulatory visit diagnoses.

MEASUREMENTS: Participants with a LVEF of 50% or greater were classified as having HF-P. Presence of cardiac and noncardiac comorbidities was obtained from health plan administrative databases.

RESULTS: Of 23,435 individuals identified with HF and LVEF information, 53% (12,407) had confirmed HF-P (mean age 79.6; 60% female). More than three-quarters of the sample had three or more co-occurring conditions in addition to HF, and half had five or more cooccurring conditions. Participants with HF-P had a slightly higher burden of comorbidity than those with HF-R (mean 4.5 vs 4.4, P = .002). Patterns of how specific conditions co-occurred did not vary in participants with preserved or reduced systolic function.

CONCLUSION: There is a high degree of comorbidity and multiple morbidity in individuals with HF. The burden and pattern of comorbidity varies only slightly in individuals with preserved or reduced LVEF. Geriatrics Society.

DOI of Published Version



J Am Geriatr Soc. 2013 Jan;61(1):26-33. doi: 10.1111/jgs.12062. Link to article on publisher's site

Journal/Book/Conference Title

Journal of the American Geriatrics Society

PubMed ID


Related Resources

Link to Article in PubMed