Randomized controlled trial of behavioral treatment for comorbid obesity and depression in women: the Be Active Trial
Department of Quantitative Health Sciences; Department of Medicine, Division of Preventive and Behavioral Medicine; Department of Medicine, Division of Cardiovascular Medicine
Obesity; Weight Loss; Depressive Disorder; Behavior Therapy; Comorbidity
Behavior and Behavior Mechanisms | Clinical Epidemiology | Mental and Social Health | Mental Disorders | Nutritional and Metabolic Diseases | Psychiatry and Psychology | Women's Health
OBJECTIVE:Depression is associated with increased risk for obesity and worse weight loss treatment outcomes. The purpose of the present study was to test the hypothesis that delivering evidence-based behavior therapy for depression before a lifestyle weight loss intervention improves both weight loss and depression.
DESIGN:In a randomized controlled trial, obese women with major depressive disorder (N=161, mean age=45.9 (s.d.: 10.8) years) were randomized to brief behavior therapy for depression treatment followed by a lifestyle intervention (BA) or a lifestyle intervention only (LI). Follow-up occurred at 6 and 12 months. Main outcome measures included weight loss and depression symptoms.
RESULTS:Intention-to-treat analyses revealed both conditions lost significant weight, but no differences between conditions in weight change at 6 months (BA=-3.0%, s.e.=-0.65%; LI=-3.7%, s.e.=0.63%; P=0.48) or 12 months (BA=-2.6%, s.e.=0.77%; LI=-3.1%, s.e.=0.74%; P=0.72). However, the BA condition evidenced significantly greater improvement in Beck Depression Inventory-II scores relative to the LI condition at both 6 months (BA mean change=-12.5, s.d.=0.85; LI mean change=-9.2, s.d.=0.80, P=0.005) and 12 months (BA mean change=-12.6, s.d.=0.97; LI mean change=-9.9, s.d.=0.93; P=0.045). Participants who experienced depression remission by 6 months (61.2%) lost greater weight (mean=-4.31%; s.e.=0.052) than those who did not (39.7%; mean=-2.47%, s.e.=0.53; P=.001).
CONCLUSION:Adding behavior therapy to a lifestyle intervention results in greater depression remission but does not improve weight loss within 1 year. Improvement in depression is associated with greater weight loss.
DOI of Published Version
Pagoto S, Schneider KL, Whited MC, Oleski JL, Merriam P, Appelhans B, Ma Y, Olendzki B, Waring ME, Busch AM, Lemon S, Ockene I, Crawford S. Randomized controlled trial of behavioral treatment for comorbid obesity and depression in women: the Be Active Trial. Int J Obes (Lond). 2013 Nov;37(11):1427-34. doi:10.1038/ijo.2013.25. Link to article on publisher's site
International journal of obesity (2005)
Pagoto, Sherry L.; Schneider, Kristin L.; Whited, Matthew C.; Oleski, Jessica L.; Merriam, Philip A.; Appelhans, Bradley M.; Ma, Yunsheng; Olendzki, Barbara C.; Waring, Molly E.; Busch, A. M.; Lemon, Stephenie C.; Ockene, Ira S.; and Crawford, Sybil L., "Randomized controlled trial of behavioral treatment for comorbid obesity and depression in women: the Be Active Trial" (2013). Quantitative Health Sciences Publications and Presentations. 1081.