Title
Humoral and Cellular Immunity to Plasmodium falciparum Merozoite Surface Protein 1 and Protection from Blood-stage Infection
UMMS Affiliation
Department of Quantitative Health Sciences; Department of Pediatrics
Publication Date
2013-7
Document Type
Article
Subjects
Malaria, Falciparum; Merozoite Surface Protein 1; Plasmodium falciparum; Immunity, Humoral; Immunity, Cellular
Disciplines
Immunity | Immunology and Infectious Disease | Parasitic Diseases | Parasitology
Abstract
Background. Acquired immunity to malaria develops with increasing age and repeated infections. Understanding immune correlates of protection from malaria infection would facilitate vaccine development and identification of biomarkers that reflect changes in susceptibility resulting from ongoing malaria control efforts.
Methods. The relationship between IgG antibody and IFN-gamma and IL-10 responses to the 42 kD C-terminal fragment of Plasmodium falciparum Merozoite Surface Protein 1 (MSP142) and risk-of-(re)infection were examined following drug-mediated clearance of parasitemia in 94 adults and 95 children in a holoendemic area of western Kenya.
Results. Positive IFN-gamma ELISA and ELISPOT responses to MSP-142 3D7 were associated with delayed time-to-(re)infection whereas high-titer IgG antibodies to MSP-142 3D7 or FVO alleles were not independently predictive of risk-of-(re)infection. When IFN-gamma and IL-10 responses were both present, the protective effect of IFN-gamma was abrogated. A Cox proportional hazard model including IFN-gamma, IL-10, MSP142 3D7 IgG antibody responses, hemoglobin S genotype, age and infection status at baseline, showed time to blood-stage infection correlated positively with IFNgamma+ responses and negatively with IL-10+ responses, younger age, and asymptomatic parasitemia.
Conclusion. Evaluating combined allele-specific cellular and humoral immunity elicited by malaria provides a more informative measure of protection relative to either measure alone.
Keywords
UMCCTS funding
DOI of Published Version
10.1093/infdis/jit134
Source
J Infect Dis. 2013 Jul;208(1):149-58. doi: 10.1093/infdis/jit134. Link to article on publisher's site
Journal/Book/Conference Title
The Journal of infectious diseases
PubMed ID
23539744
Related Resources
Repository Citation
Moormann, Ann M.; Sumba, Peter Odada; Chelimo, Kiprotich; Fang, Hua; Tisch, Daniel J.; Dent, Arlene E.; John, Chandy C.; Long, Carole A.; Vulule, John; and Kazura, James W., "Humoral and Cellular Immunity to Plasmodium falciparum Merozoite Surface Protein 1 and Protection from Blood-stage Infection" (2013). Quantitative Health Sciences Publications and Presentations. 1069.
https://escholarship.umassmed.edu/qhs_pp/1069
