Humoral and Cellular Immunity to Plasmodium falciparum Merozoite Surface Protein 1 and Protection from Blood-stage Infection
Authors
Moormann, Ann M.Sumba, Peter Odada
Chelimo, Kiprotich
Fang, Hua
Tisch, Daniel J.
Dent, Arlene E.
John, Chandy C.
Long, Carole A.
Vulule, John
Kazura, James W.
Document Type
Journal ArticlePublication Date
2013-07-01Keywords
Malaria, FalciparumMerozoite Surface Protein 1
Plasmodium falciparum
Immunity, Humoral
Immunity, Cellular
UMCCTS funding
Immunity
Immunology and Infectious Disease
Parasitic Diseases
Parasitology
Metadata
Show full item recordAbstract
Background. Acquired immunity to malaria develops with increasing age and repeated infections. Understanding immune correlates of protection from malaria infection would facilitate vaccine development and identification of biomarkers that reflect changes in susceptibility resulting from ongoing malaria control efforts. Methods. The relationship between IgG antibody and IFN-gamma and IL-10 responses to the 42 kD C-terminal fragment of Plasmodium falciparum Merozoite Surface Protein 1 (MSP142) and risk-of-(re)infection were examined following drug-mediated clearance of parasitemia in 94 adults and 95 children in a holoendemic area of western Kenya. Results. Positive IFN-gamma ELISA and ELISPOT responses to MSP-142 3D7 were associated with delayed time-to-(re)infection whereas high-titer IgG antibodies to MSP-142 3D7 or FVO alleles were not independently predictive of risk-of-(re)infection. When IFN-gamma and IL-10 responses were both present, the protective effect of IFN-gamma was abrogated. A Cox proportional hazard model including IFN-gamma, IL-10, MSP142 3D7 IgG antibody responses, hemoglobin S genotype, age and infection status at baseline, showed time to blood-stage infection correlated positively with IFNgamma+ responses and negatively with IL-10+ responses, younger age, and asymptomatic parasitemia. Conclusion. Evaluating combined allele-specific cellular and humoral immunity elicited by malaria provides a more informative measure of protection relative to either measure alone.Source
J Infect Dis. 2013 Jul;208(1):149-58. doi: 10.1093/infdis/jit134. Link to article on publisher's site
DOI
10.1093/infdis/jit134Permanent Link to this Item
http://hdl.handle.net/20.500.14038/46605PubMed ID
23539744Related Resources
ae974a485f413a2113503eed53cd6c53
10.1093/infdis/jit134