Late effects in 164 patients with rhabdomyosarcoma of the bladder/prostate region: a report from the international workshop
Quality Assurance Review Center
Health Services Administration | Neoplasms | Oncology | Radiology
PURPOSE: We determined the late sequelae in children and adolescents with rhabdomyosarcoma of the bladder/prostate treated in the United States, Canada and selected Western European countries, primarily France, Germany, Italy and the United Kingdom, from 1979 to 1998.
MATERIALS AND METHODS: We used a data collection form to record data from patient records available at the group statistical centers.
RESULTS: A total of 164 patient charts had sufficient data available to be included in the study. Median patient age at diagnosis was 2.4 years. Median length of followup was approximately 8 years (range 3 to 24). Of the patients with available data 78 did not undergo cystectomy, 49 underwent partial cystectomy and 34 underwent complete cystectomy. Urinary continence was assessed at age 6 years or older in 62 patients who did not undergo cystectomy. Of these patients 43 (69%) were continent, 16 had nocturnal incontinence and 9 had diurnal incontinence. Of 44 patients who underwent partial cystectomy and had pertinent followup data 32 (73%) were continent, and 12 had nocturnal and/or diurnal incontinence. Only 11 patients underwent urodynamic investigation. Other nephrourological complications consisted of 3 or more urinary tract infections in 29 of 53 patients, abnormal renal function in 19 of 48 (tubulopathy 14, increased creatinine/blood urea nitrogen 5), chronic hematuria in 13 of 51 and hydronephrosis in 8 of 54 with available data. Vesicoureteral reflux, urinary stones and bowel problems were infrequent.
CONCLUSIONS: Of the patients 48% had a relatively intact bladder after biopsy only. However, 31% of patients 6 years or older had some urinary incontinence, as did 27% of patients who had undergone partial cystectomy. In addition, 55% of all patients had 3 or more urinary tract infections, 40% had decreased renal function and 25% had chronic hematuria. Other complications were present in 15% or less of the patients with available data.
DOI of Published Version
J Urol. 2006 Nov;176(5):2190-4; discussion 2194-5. Link to article on publisher's site
The Journal of urology
Raney B, Anderson J, Jenney M, Arndt C, Brecht I, Carli M, Bisogno G, Oberlin O, Rey A, Treuner J, Ullrich F, Stevens M. (2006). Late effects in 164 patients with rhabdomyosarcoma of the bladder/prostate region: a report from the international workshop. IROC Rhode Island (QARC) Publications. https://doi.org/10.1016/j.juro.2006.07.064. Retrieved from https://escholarship.umassmed.edu/qarc/48