Image based feasibility of renal sparing surgery for very low risk unilateral Wilms tumors: a report from the Children's Oncology Group
Quality Assurance Review Center
Health Services Administration | Neoplasms | Oncology | Pediatrics | Radiology | Urology
PURPOSE: Nephrectomy with lymph node sampling is the recommended treatment for children with unilateral Wilms tumor under the Children's Oncology Group protocols. Using radiological assessment, we determined the feasibility of performing partial nephrectomy in a select group of patients with very low risk unilateral Wilms tumor.
MATERIALS AND METHODS: We reviewed imaging studies of 60 patients with a mean age of less than 2 years with very low risk unilateral Wilms tumor (mean weight less than 550 gm) to assess the feasibility of partial nephrectomy. We evaluated percentage of salvageable parenchyma, tumor location and anatomical features preventing a nephron sparing approach.
RESULTS: A linear relationship exists between tumor weight and computerized tomography estimated tumor volume. Mean tumor weight in the study population was 315 gm. Partial nephrectomy was deemed feasible in only 5 of 60 patients (8%).
CONCLUSIONS: When considering a select population with very low risk unilateral Wilms tumor (lower volume tumor), only a small percentage of nonpretreated patients are candidates for nephron sparing surgery. .
DOI of Published Version
J Urol. 2013 Nov;190(5):1846-51. doi: 10.1016/j.juro.2013.05.060. Epub 2013 May 30. Link to article on publisher's site
The Journal of urology
Ferrer, F. A.; Rosen, N.; Herbst, K.; Fernandez, C. V.; Khanna, G.; Dome, J. S.; Mullen, E.; Gow, K. W.; Barnhart, D. C.; Shamberger, R. C.; Ritchey, M.; and Ehrlich, P., "Image based feasibility of renal sparing surgery for very low risk unilateral Wilms tumors: a report from the Children's Oncology Group" (2013). IROC Rhode Island (QARC) Publications. 26.