Kinetic Mechanism of Nicotinamide N-Methyltransferase.
Thompson Lab; Department of Biochemistry and Molecular Pharmacology; Program in Chemical Biology
Biochemistry | Enzymes and Coenzymes | Medicinal-Pharmaceutical Chemistry
Nicotinamide N-methyltransferase (NNMT) catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to nicotinamide, pyridine, and other structural analogues. Aberrantly increased NNMT activity results in the depletion of SAM, nicotinamide (NAM), and nicotinamide adenine dinucleotide (NAD
DOI of Published Version
Biochemistry. 2018 Sep 25;57(38):5524-5532. doi: 10.1021/acs.biochem.8b00775. Epub 2018 Sep 10.