Title
Kinetic Mechanism of Nicotinamide N-Methyltransferase.
UMMS Affiliation
Thompson Lab; Department of Biochemistry and Molecular Pharmacology; Program in Chemical Biology
Publication Date
2018-09-25
Document Type
Article
Disciplines
Biochemistry | Enzymes and Coenzymes | Medicinal-Pharmaceutical Chemistry
Abstract
Nicotinamide N-methyltransferase (NNMT) catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to nicotinamide, pyridine, and other structural analogues. Aberrantly increased NNMT activity results in the depletion of SAM, nicotinamide (NAM), and nicotinamide adenine dinucleotide (NAD
DOI of Published Version
10.1021/acs.biochem.8b00775
Source
Biochemistry. 2018 Sep 25;57(38):5524-5532. doi: 10.1021/acs.biochem.8b00775. Epub 2018 Sep 10.
Journal/Book/Conference Title
Biochemistry
Related Resources
PubMed ID
30148963
Repository Citation
Loring, Heather S. and Thompson, Paul R., "Kinetic Mechanism of Nicotinamide N-Methyltransferase." (2018). University of Massachusetts Medical School Publications. 10.
https://escholarship.umassmed.edu/publications/10