Title

Kinetic Mechanism of Nicotinamide N-Methyltransferase.

UMMS Affiliation

Thompson Lab; Department of Biochemistry and Molecular Pharmacology; Program in Chemical Biology

Publication Date

2018-09-25

Document Type

Article

Disciplines

Biochemistry | Enzymes and Coenzymes | Medicinal-Pharmaceutical Chemistry

Abstract

Nicotinamide N-methyltransferase (NNMT) catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to nicotinamide, pyridine, and other structural analogues. Aberrantly increased NNMT activity results in the depletion of SAM, nicotinamide (NAM), and nicotinamide adenine dinucleotide (NAD

DOI of Published Version

10.1021/acs.biochem.8b00775

Source

Biochemistry. 2018 Sep 25;57(38):5524-5532. doi: 10.1021/acs.biochem.8b00775. Epub 2018 Sep 10.

Journal/Book/Conference Title

Biochemistry

Related Resources

Link to article in PubMed

PubMed ID

30148963

Share

COinS