Neurocognitive function of 10-year-old multiples born less than 28 weeks of gestational age

UMMS Affiliation

Department of Psychiatry

Publication Date


Document Type



Pediatrics | Psychiatry | Psychiatry and Psychology


INTRODUCTION: Few studies have examined the relationship between birth plurality and neurocognitive function among children born extremely preterm.

STUDY DESIGN: We compared rates of Z-scores < /=-2 on 18 tests of neurocognitive function and academic achievement at age 10 years in 245 children arising from twin pregnancies, 55 from triplet pregnancies, and 6 from a septuplet pregnancy to that of 568 singletons, all of whom were born before the 28th week of gestation.

RESULTS: In total, 874 children were evaluated at the age of 10 years. After adjusting for confounders, children of multifetal pregnancies performed significantly better on one of six subtests of executive function than their singleton peers. Performance was similar on all other assessments of intelligence, language, academic achievement, processing speed, visual perception, and fine motor skills.

CONCLUSION: We found no evidence that children born of multifetal pregnancies had worse scores than their singleton peers on assessments of neurocognitive and academic function.


neurocognitive function, executive function, functional development, intelligence, academic achievement, multi-fetal pregnancy, twin pregnancy

DOI of Published Version



Logan JW, Allred EN, Msall ME, Joseph RM, Michael O'Shea TT, Heeren T, Leviton A, Kuban KCK; ELGAN Study Investigators. Neurocognitive function of 10-year-old multiples born less than 28 weeks of gestational age. J Perinatol. 2019 Feb;39(2):237-247. doi: 10.1038/s41372-018-0273-x. Epub 2018 Nov 21. PMID: 30464222; PMCID: PMC6351188. Link to article on publisher's site

Journal/Book/Conference Title

Journal of perinatology : official journal of the California Perinatal Association


The ELGAN Study Investigators for the University of Massachusetts Medical School, Worcester MA: Jean Frazier, Lauren Venuti, Beth Powers, Ann Foley, Brian Dessureau, Molly Wood, Jill Damon-Minow.

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