Resting-state functional connectivity, cortical GABA, and neuroactive steroids in peripartum and peripartum depressed women: a functional magnetic resonance imaging and spectroscopy study
Authors
Deligiannidis, Kristina M.Fales, Christina L.
Kroll-Desrosiers, Aimee
Shaffer, Scott A.
Villamarin, Vanessa
Tan, Yanglan
Hall, Janet E.
Frederick, Blaise B.
Sikoglu, Elif M.
Edden, Richard A.
Rothschild, Anthony J.
Moore, Constance M.
UMass Chan Affiliations
Center for Comparative NeuroimagingDepartment of Biochemistry and Molecular Pharmacology
Mass Spectrometry Facility
Department of Quantitative Health Sciences
Department of Psychiatry, Center for Psychopharmacologic Research and Treatment
Document Type
Journal ArticlePublication Date
2019-02-01Keywords
Gonadal hormonesPrefrontal cortex
Biochemistry
Endocrine System
Female Urogenital Diseases and Pregnancy Complications
Hormones, Hormone Substitutes, and Hormone Antagonists
Nervous System
Neuroscience and Neurobiology
Pharmacology, Toxicology and Environmental Health
Psychiatry
Psychiatry and Psychology
Reproductive and Urinary Physiology
Women's Health
Metadata
Show full item recordAbstract
Postpartum depression (PPD) is associated with abnormalities in resting-state functional connectivity (RSFC) but the underlying neurochemistry is unclear. We hypothesized that peripartum GABAergic neuroactive steroids (NAS) are related to cortical GABA concentrations and RSFC in PPD as compared to healthy comparison women (HCW). To test this, we measured RSFC with fMRI and GABA+/Creatine (Cr) concentrations with proton magnetic resonance spectroscopy ((1)H MRS) in the pregenual anterior cingulate (pgACC) and occipital cortices (OCC) and quantified peripartum plasma NAS. We examined between-group differences in RSFC and the relationship between cortical GABA+/Cr concentrations with RSFC. We investigated the relationship between NAS, RSFC and cortical GABA+/Cr concentrations. Within the default mode network (DMN) an area of the dorsomedial prefrontal cortex (DMPFC) had greater connectivity with the rest of the DMN in PPD (peak voxel: MNI coordinates (2, 58, 32), p = 0.002) and was correlated to depression scores (peak HAM-D17 voxel: MNI coordinates (0, 60, 34), p = 0.008). pgACC GABA+/Cr correlated positively with DMPFC RSFC in a region spanning the right anterior/posterior insula and right temporal pole (r = +0.661, p = 0.000). OCC GABA+/Cr correlated positively with regions spanning both amygdalae (right amygdala: r = +0.522, p = 0.000; left amygdala: r = +0.651, p = 0.000) as well as superior parietal areas. Plasma allopregnanolone was higher in PPD (p = 0.03) and positively correlated with intra DMPFC connectivity (r = +0.548, p = 0.000) but not GABA+/Cr. These results provide initial evidence that PPD is associated with altered DMN connectivity; cortical GABA+/Cr concentrations are associated with postpartum RSFC and allopregnanolone is associated with postpartum intra-DMPFC connectivity.Source
Neuropsychopharmacology. 2019 Feb;44(3):546-554. doi: 10.1038/s41386-018-0242-2. Epub 2018 Oct 17. Link to article on publisher's site
DOI
10.1038/s41386-018-0242-2Permanent Link to this Item
http://hdl.handle.net/20.500.14038/46323PubMed ID
30327498Related Resources
ae974a485f413a2113503eed53cd6c53
10.1038/s41386-018-0242-2