Title

Health-related quality of life in remitted psychotic depression

UMMS Affiliation

Department of Psychiatry

Publication Date

2019-09-01

Document Type

Article

Disciplines

Mental and Social Health | Psychiatry | Psychiatry and Psychology

Abstract

BACKGROUND: Some patients with major depression continue to demonstrate deficits in health-related quality of life (HRQL) following remission. No data exist, however, regarding HRQL in remitted psychotic depression. In this study, we aimed to characterize HRQL in patients with psychotic depression receiving controlled pharmacotherapy.

METHODS: This is a secondary analysis of a randomized controlled trial studying continuation pharmacotherapy of psychotic depression. We compared participants' HRQL (measured using the SF-36) between baseline and remission and to population norms. We also compared SF-36 scores stratified by age and gender and examined the correlation between SF-36 scores and medical burden, depression score and neuropsychological performance in remission.

RESULTS: SF-36 scores were significantly lower than population norms at baseline, but improved following remission to the level of population norms. Neither SF-36 scores nor magnitude of SF-36 improvement differed substantially between genders or between younger and older participants. In remission, depression scores were correlated with most SF-36 scales and medical burden was correlated with SF-36 scales measuring physical symptoms. Neuropsychological measures were generally not correlated with SF-36 scores.

LIMITATIONS: This study was a secondary analysis not powered specifically to measure HRQL as an outcome variable and the SF-36 was the only HRQL measure used.

CONCLUSIONS: Participants with remitted psychotic depression demonstrated levels of HRQL comparable to population norms, despite marked impairment in HRQL when acutely ill. This finding suggests that, when treated in a rigorous manner, many patients with this severe illness improve significantly from a clinical and HRQL perspective.

DOI of Published Version

10.1016/j.jad.2019.05.068

Source

J Affect Disord. 2019 May 28;256:373-379. doi: 10.1016/j.jad.2019.05.068. [Epub ahead of print] Link to article on publisher's site

Journal/Book/Conference Title

Journal of affective disorders

Related Resources

Link to Article in PubMed

PubMed ID

31207561

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