Department of Medicine; Department of Psychiatry
Mental and Social Health | Neurology | Neuroscience and Neurobiology | Pathological Conditions, Signs and Symptoms | Psychiatry | Psychiatry and Psychology | Therapeutics
While reducing the burden of brain disorders remains a top priority of organizations like the World Health Organization and National Institutes of Health, the development of novel, safe and effective treatments for brain disorders has been slow. In this paper, we describe the state of the science for an emerging technology, real time functional magnetic resonance imaging (rtfMRI) neurofeedback, in clinical neurotherapeutics. We review the scientific potential of rtfMRI and outline research strategies to optimize the development and application of rtfMRI neurofeedback as a next generation therapeutic tool. We propose that rtfMRI can be used to address a broad range of clinical problems by improving our understanding of brain-behavior relationships in order to develop more specific and effective interventions for individuals with brain disorders. We focus on the use of rtfMRI neurofeedback as a clinical neurotherapeutic tool to drive plasticity in brain function, cognition, and behavior. Our overall goal is for rtfMRI to advance personalized assessment and intervention approaches to enhance resilience and reduce morbidity by correcting maladaptive patterns of brain function in those with brain disorders.
Brain-computer interface, Neurofeedback, Neurotherapeutic, Real time fMRI
Rights and Permissions
© 2014 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-SA license (http://creativecommons.org/licenses/by-nc-sa/3.0/).
DOI of Published Version
Neuroimage Clin. 2014 Jul 10;5:245-55. doi: 10.1016/j.nicl.2014.07.002. eCollection 2014. Link to article on publisher's site
Stoeckel, L. E. and Brewer, Judson A., "Optimizing real time fMRI neurofeedback for therapeutic discovery and development" (2014). Psychiatry Publications and Presentations. 827.
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 License.
Mental and Social Health Commons, Neurology Commons, Neuroscience and Neurobiology Commons, Pathological Conditions, Signs and Symptoms Commons, Psychiatry Commons, Psychiatry and Psychology Commons, Therapeutics Commons