Antidepressant Medication Treatment and Risk of Death
Department of Psychiatry
Medical Pharmacology | Mental and Social Health | Psychiatry | Psychiatry and Psychology
OBJECTIVE: Although previous studies have assessed whether depression is a mortality risk factor, few have examined whether antidepressant medications (ADMs) influence mortality risk.
METHODS: We estimated hazards of 1-year all-cause mortality associated with ADMs, with use occurring within 90 days of depression diagnosis among 720 821 patients who received treatment in a Veterans Health Administration facility during fiscal year 2006. We addressed treatment selection biases using conventional Cox regression, propensity-stratified Cox regression (propensity score), and 2 forms of marginal structural models. Models accounted for multiple potential clinical and demographic confounders, and sensitivity analyses compared findings by antidepressant class.
RESULTS: Antidepressant medication use compared with no use was associated with significantly lower hazards of 1-year mortality risk in Cox (hazard ratio [HR], 0.93; 95% confidence interval [CI], 0.90-0.97) and propensity score estimates (HR, 0.94; 95% CI, 0.91-0.98), whereas marginal structural model-based estimates showed no difference in mortality risk when the exposure was specified as "as-treated" in every 90-day intervals of the 1-year follow-up (HR, 0.91; 95% CI, 0.66-1.26) but showed increased risk when specified as "intent-to-treat" (HR, 1.07; 95% CI, 1.02-1.13).
CONCLUSIONS: Among patients treated with ADMs belonging to a single class in the first 90 days, there were no significant differences in 1-year all-cause mortality risks. When accounting for clinical and demographic characteristics and treatment selection bias, ADM use was associated with no excess harm.
DOI of Published Version
J Clin Psychopharmacol. 2016 Oct;36(5):445-52. doi: 10.1097/JCP.0000000000000545. Link to article on publisher's site
Journal of clinical psychopharmacology
Zivin, Kara; Kim, H. Myra; Yosef, Matheos; Maust, Donovan T.; Valenstein, Marcia; Smith, Eric G.; and Davydow, Dimitry S., "Antidepressant Medication Treatment and Risk of Death" (2016). Psychiatry Publications and Presentations. 785.