The Prevalence of Bipolar Disorders and Association With Quality of Life in a Cohort of Patients With Multiple Sclerosis
Department of Neurology; Department of Psychiatry, Center for Psychopharmacologic Research and Treatment; Systems and Psychosocial Advances Research Center; Graduate School of Biomedical Sciences, Millennium PhD Program
Mental and Social Health | Nervous System Diseases | Neuroscience and Neurobiology | Psychiatry | Psychiatry and Psychology
Clinical observations of mood instability in multiple sclerosis (MS) have led to the hypothesis that bipolar disorder (BD) may be more prevalent in persons with MS than in the general population. This cross-sectional study assesses the prevalence of BD among patients with MS using standardized psychiatric diagnostic interviews and evaluates quality of life. This study demonstrates a higher prevalence of BD in patients with MS compared with the general population. It also reveals the negative impact of BD on quality of life, raises the concern that BD can occur before the onset of neurological symptoms in MS, and suggests that, in some cases, BD may delay diagnosis of MS.
DOI of Published Version
J Neuropsychiatry Clin Neurosci. 2017 Winter;29(1):45-51. doi: 10.1176/appi.neuropsych.15120403. Epub 2016 Aug 19. Link to article on publisher's site
The Journal of neuropsychiatry and clinical neurosciences
Jun-O'Connell AH, Butala AA, Morales IB, Henninger N, Deligiannidis KM, Byatt N, Ionete C. (2017). The Prevalence of Bipolar Disorders and Association With Quality of Life in a Cohort of Patients With Multiple Sclerosis. Psychiatry Publications. https://doi.org/10.1176/appi.neuropsych.15120403. Retrieved from https://escholarship.umassmed.edu/psych_pp/768