The Prevalence of Bipolar Disorders and Association With Quality of Life in a Cohort of Patients With Multiple Sclerosis

UMMS Affiliation

Department of Neurology; Department of Psychiatry, Center for Psychopharmacologic Research and Treatment; Systems and Psychosocial Advances Research Center; Graduate School of Biomedical Sciences, Millennium PhD Program

Publication Date


Document Type



Mental and Social Health | Nervous System Diseases | Neuroscience and Neurobiology | Psychiatry | Psychiatry and Psychology


Clinical observations of mood instability in multiple sclerosis (MS) have led to the hypothesis that bipolar disorder (BD) may be more prevalent in persons with MS than in the general population. This cross-sectional study assesses the prevalence of BD among patients with MS using standardized psychiatric diagnostic interviews and evaluates quality of life. This study demonstrates a higher prevalence of BD in patients with MS compared with the general population. It also reveals the negative impact of BD on quality of life, raises the concern that BD can occur before the onset of neurological symptoms in MS, and suggests that, in some cases, BD may delay diagnosis of MS.

DOI of Published Version



J Neuropsychiatry Clin Neurosci. 2017 Winter;29(1):45-51. doi: 10.1176/appi.neuropsych.15120403. Epub 2016 Aug 19. Link to article on publisher's site

Journal/Book/Conference Title

The Journal of neuropsychiatry and clinical neurosciences


Co-author Nils Henninger is a doctoral student in the Millennium PhD Program (MPP) in the Graduate School of Biomedical Sciences (GSBS) at UMass Medical School.

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Link to Article in PubMed

PubMed ID