Perisylvian GABA levels in schizophrenia and bipolar disorder

UMMS Affiliation

Department of Psychiatry

Publication Date


Document Type



Mental and Social Health | Mental Disorders | Neuroscience and Neurobiology | Psychiatry | Psychiatry and Psychology


The aim of this study is to measure GABA levels of perisylvian cortices in schizophrenia and bipolar disorder patients, using proton magnetic resonance spectroscopy (1H-MRS). Patients with schizophrenia (n=25), bipolar I disorder (BD-I; n=28) and bipolar II disorder (BD-II; n=20) were compared with healthy controls (n=30). 1H-MRS data was acquired using a Siemens 3T whole body scanner to quantify right and left perisylvian structures' (including superior temporal lobes) GABA levels. Right perisylvian GABA values differed significantly between groups [chi2=9.62, df: 3, p=0.022]. GABA levels were significantly higher in the schizophrenia group compared with the healthy control group (p=0.002). Furthermore, Chlorpromazine equivalent doses of antipsychotics correlated with right hemisphere GABA levels (r2=0.68, p=0.006, n=33). GABA levels are elevated in the right hemisphere in patients with schizophrenia in comparison to bipolar disorder and healthy controls. The balance between excitatory and inhibitory controls over the cortical circuits may have direct relationship with GABAergic functions in auditory cortices. In addition, GABA levels may be altered by brain regions of interest, psychotropic medications, and clinical stage in schizophrenia and bipolar disorder.


Auditory cortex, Bipolar disorder, GABA, Magnetic resonance spectroscopy, Schizophrenia

DOI of Published Version



Neurosci Lett. 2017 Jan 10;637:70-74. doi: 10.1016/j.neulet.2016.11.051. Epub 2016 Nov 24. Link to article on publisher's site

Journal/Book/Conference Title

Neuroscience letters

Related Resources

Link to Article in PubMed

PubMed ID