Perisylvian GABA levels in schizophrenia and bipolar disorder
Department of Psychiatry
Mental and Social Health | Mental Disorders | Neuroscience and Neurobiology | Psychiatry | Psychiatry and Psychology
The aim of this study is to measure GABA levels of perisylvian cortices in schizophrenia and bipolar disorder patients, using proton magnetic resonance spectroscopy (1H-MRS). Patients with schizophrenia (n=25), bipolar I disorder (BD-I; n=28) and bipolar II disorder (BD-II; n=20) were compared with healthy controls (n=30). 1H-MRS data was acquired using a Siemens 3T whole body scanner to quantify right and left perisylvian structures' (including superior temporal lobes) GABA levels. Right perisylvian GABA values differed significantly between groups [chi2=9.62, df: 3, p=0.022]. GABA levels were significantly higher in the schizophrenia group compared with the healthy control group (p=0.002). Furthermore, Chlorpromazine equivalent doses of antipsychotics correlated with right hemisphere GABA levels (r2=0.68, p=0.006, n=33). GABA levels are elevated in the right hemisphere in patients with schizophrenia in comparison to bipolar disorder and healthy controls. The balance between excitatory and inhibitory controls over the cortical circuits may have direct relationship with GABAergic functions in auditory cortices. In addition, GABA levels may be altered by brain regions of interest, psychotropic medications, and clinical stage in schizophrenia and bipolar disorder.
Auditory cortex, Bipolar disorder, GABA, Magnetic resonance spectroscopy, Schizophrenia
DOI of Published Version
Neurosci Lett. 2017 Jan 10;637:70-74. doi: 10.1016/j.neulet.2016.11.051. Epub 2016 Nov 24. Link to article on publisher's site
Atagun MI, Sikoglu EM, Soykan C, Serdar Suleyman C, Ulusoy-Kaymak S, Caykoylu A, Algin O, Phillips ML, Ongur D, Moore CM. (2017). Perisylvian GABA levels in schizophrenia and bipolar disorder. Psychiatry Publications and Presentations. https://doi.org/10.1016/j.neulet.2016.11.051. Retrieved from https://escholarship.umassmed.edu/psych_pp/764