Peripartum depression and anxiety as an integrative cross domain target for psychiatric preventative measures

UMMS Affiliation

Department of Psychiatry

Publication Date


Document Type



Maternal and Child Health | Mental and Social Health | Neuroscience and Neurobiology | Psychiatry | Psychiatry and Psychology | Women's Health


Exposure to high levels of early life stress has been identified as a potent risk factor for neurodevelopmental delays in infants, behavioral problems and autism in children, but also for several psychiatric illnesses in adulthood, such as depression, anxiety, autism, and posttraumatic stress disorder. Despite having robust adverse effects on both mother and infant, the pathophysiology of peripartum depression and anxiety are poorly understood. The objective of this review is to highlight the advantages of using an integrated approach addressing several behavioral domains in both animal and clinical studies of peripartum depression and anxiety. It is postulated that a greater focus on integrated cross domain studies will lead to advances in treatments and preventative measures for several disorders associated with peripartum depression and anxiety.

DOI of Published Version



Behav Brain Res. 2014 Apr 4. doi: 10.1016/j.bbr.2014.03.039. Link to article on publisher's site

Journal/Book/Conference Title

Behavioural brain research

Related Resources

Link to Article in PubMed

PubMed ID