The association between concurrent psychotropic medications and self-reported adherence with taking a mood stabilizer in bipolar disorder
Authors
Bauer, MichaelGlenn, Tasha
Grof, Paul
Marsh, Wendy K.
Sagduyu, Kemal
Alda, Martin
Murray, Greg
Lewitzka, Ute
Schmid, Rita
Haack, Sara
Whybrow, Peter C.
UMass Chan Affiliations
Department of PsychiatryDocument Type
Journal ArticlePublication Date
2010-01-01Keywords
AdultAffect
Antimanic Agents
Antipsychotic Agents
Attitude to Health
Bipolar Disorder
Female
Humans
Male
Middle Aged
*Patient Compliance
Psychiatric Status Rating Scales
Questionnaires
*Self Concept
Mental and Social Health
Psychiatry
Psychiatry and Psychology
Metadata
Show full item recordAbstract
OBJECTIVE: Multiple psychotropic medications are routinely prescribed to treat bipolar disorder, creating complex medication regimens. This study investigated whether the daily number of psychotropic medications or the daily number of pills were associated with self-reported adherence with taking a mood stabilizer. METHODS: Patients self-reported their mood and medications taken daily for about 6 months. Adherence was defined as taking at least one pill of any mood stabilizer daily. Univariate general linear models (GLMs) were used to estimate if adherence was associated with the number of daily medications and the number of pills, controlling for age. The association between mean daily dosage of mood stabilizer and adherence was also estimated using a GLM. RESULTS: Three hundred and twelve patients (mean age 38.4 +/- 10.9 years) returned 58,106 days of data and took a mean of 3.1 +/- 1.6 psychotropic medications daily (7.0 +/- 4.2 pills). No significant association was found between either the daily number of medications or the daily number of pills and adherence. For most mood stabilizers, patients with lower adherence took a significantly smaller mean daily dosage. CONCLUSIONS: The number of concurrent psychotropic medications may not be associated with adherence in bipolar disorder. Patients with lower adherence may be taking smaller dosages of mood stabilizers.Source
Bauer, M., Glenn, T., Grof, P., Marsh, W., Sagduyu, K., Alda, M., Murray, G., Lewitzka, U., Schmid, R., Haack, S. and Whybrow, P. C. (2010), The association between concurrent psychotropic medications and self-reported adherence with taking a mood stabilizer in bipolar disorder. Hum. Psychopharmacol. Clin. Exp., 25: 47–54. doi: 10.1002/hup.1077. Link to article on publisher's siteDOI
10.1002/hup.1077Permanent Link to this Item
http://hdl.handle.net/20.500.14038/46062PubMed ID
20033908Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1002/hup.1077