Manic episode after total abdominal hysterectomy with bilateral salpingo-oophorectomy: case report

UMMS Affiliation

Department of Psychiatry



Document Type


Medical Subject Headings

Antimanic Agents; Bipolar Disorder; Female; *Health Status; Humans; Hysterectomy; Middle Aged; Ovariectomy; Women's Health


Psychiatry | Psychiatry and Psychology


OBJECTIVE: Times of rapid decline in reproductive hormones have been associated with mood episode onset, and the menopausal transition confers an increased risk of depression. Mood state in women with bipolar disorder during the rapid decline in reproductive hormones resulting from surgical menopause has not been reported.

METHODS: The case of a 46-year-old woman with bipolar disorder presenting to her psychiatrist after total abdominal hysterectomy with bilateral salpingo-oophorectomy is described.

RESULTS: A manic episode was diagnosed, with onset 10 days after surgical menopause.

CONCLUSIONS: Surgical menopause may place a woman with bipolar disorder at greater risk of mood episodes. In particular, risk of mania must be considered.


Citation: Menopause. 2012 Apr;19(4):476-8. Link to article on publisher's site

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