Title
The differential diagnosis of childhood- and young adult-onset disorders that include psychosis
UMMS Affiliation
Department of Psychiatry
Publication Date
2009-02-07
Document Type
Article
Subjects
Adolescent; Age of Onset; Child; Diagnosis, Differential; Humans; Mental Disorders; Mental Retardation; Psychotic Disorders; Young Adult
Disciplines
Psychiatry
Abstract
The evaluation of psychotic individuals for inherited or congenital etiologies is fraught with complexity. The authors reviewed the published literature and found 62 congenital disorders that include psychosis. Their prevalence, workup, genetics, and associated neuropsychiatric features are described. Eighteen disorders (29%) have distinct phenotypes ("doorway diagnoses"); 17 disorders (27%) are associated with mental retardation; and 45 disorders (73%) have prominent neurological signs. Thirty-four disorders (55%) can present without such distinct characteristics, and are thus more readily overlooked. We recommend a systematic and cost-effective differential diagnostic approach based on estimated prevalence and most prominent associated signs.
DOI of Published Version
10.1176/appi.neuropsych.20.4.409
Source
J Neuropsychiatry Clin Neurosci. 2008 Fall;20(4):409-18. Link to article on publisher's site
Journal/Book/Conference Title
The Journal of neuropsychiatry and clinical neurosciences
Related Resources
PubMed ID
19196925
Repository Citation
Lauterbach MD, Stanislawski-Zygaj AL, Benjamin S. (2009). The differential diagnosis of childhood- and young adult-onset disorders that include psychosis. Psychiatry Publications and Presentations. https://doi.org/10.1176/appi.neuropsych.20.4.409. Retrieved from https://escholarship.umassmed.edu/psych_pp/468