Title
Magnetic Resonance Imaging Studies in Early Onset Bipolar Disorder: An Updated Review
UMMS Affiliation
Department of Psychiatry
Publication Date
2009-4
Document Type
Article
Subjects
Bipolar Disorder; Magnetic Resonance Imaging; Adolescent
Disciplines
Psychiatry
Abstract
Over the past 5–10 years, advances in neuroimaging methods and study designs have begun to appear in the literature of early-onset bipolar disorder (onset before 18 years of age). This article contains an updated review of the literature regarding neuroimaging in youths with bipolar disorder (BPD), highlighting important new study designs and techniques. Overall, structural, functional (fMRI) and magnetic resonance spectroscopy (MRS) report consistent abnormalities in regions of the frontal lobe and limbic structures. Functional MRI and MRS studies also frequently report striatal and thalamic abnormalities in early-onset BPD. Future neuroimaging studies in youths with BPD should include longitudinal studies incorporating multimodal neuroimaging techniques.
DOI of Published Version
10.1016/j.chc.2008.12.004
Source
Janine Terry, Melissa Lopez-Larson, Jean A. Frazier. Magnetic Resonance Imaging Studies in Early Onset Bipolar Disorder: An Updated Review. Child and Adolescent Psychiatric Clinics of North America - April 2009 (Vol. 18, Issue 2, Pages 421-439, DOI: 10.1016/j.chc.2008.12.004).
Journal/Book/Conference Title
Child and Adolescent Psychiatric Clinics of North America
Repository Citation
Terry JE, Lopez-Larson MP, Frazier JA. (2009). Magnetic Resonance Imaging Studies in Early Onset Bipolar Disorder: An Updated Review. Psychiatry Publications. https://doi.org/10.1016/j.chc.2008.12.004. Retrieved from https://escholarship.umassmed.edu/psych_pp/443