Title

Treatment of early-onset schizophrenia spectrum disorders (TEOSS): demographic and clinical characteristics

Authors

Jean A. Frazier, University of Massachusetts Medical SchoolFollow
Jon McClellan, University of Washington
Robert L. Findling, Case Western Reserve University
Benedetto Vitiello, National Institute of Mental Health
Robert Anderson, University of North Carolina
Benjamin Zablotsky, Harvard Medical School
Emily Williams, University of North Carolina
Nora K. McNamara, Case Western Reserve University
Joseph A. Jackson, Harvard Medical School
Louise Ritz, National Institute of Mental Health
Stefanie A. Hlastala, University of Washington
Leslie Pierson, University of Washington
Jennifer A. Varley, University of Washington
Madeline Puglia, University of North Carolina at Chapel Hill
Ann E. Maloney, Maine Medical Center
Denisse Ambler, University of Washington
Tyehimba Hunt-Harrison, University of Washington
Robert M. Hamer, University of North Carolina
Nancy Noyes, Harvard Medical School
Jeffrey A. Lieberman, University of North Carolina
Linmarie Sikich, University of North Carolina

UMMS Affiliation

Department of Psychiatry

Publication Date

2007-08-02

Document Type

Article

Subjects

Adolescent; Adult; Age of Onset; Antipsychotic Agents; Brain; Brief Psychiatric Rating Scale; Child; Cognition Disorders; Female; Humans; Male; Neuropsychological Tests; Prevalence; Psychotic Disorders; Schizophrenia; Schizophrenic Psychology; Severity of Illness Index

Disciplines

Psychiatry

Abstract

OBJECTIVE: We examined baseline demographic and clinical profiles of youths enrolled from 2001 to 2006 in the publicly funded multicenter, randomized controlled trial Treatment of Early-Onset Schizophrenia Spectrum Disorders.

METHOD: Youths (8-19 years) with schizophrenia (SZ) and schizoaffective disorder were recruited at four academic sites. Diagnosis was made via structured and clinical interviews. Assessments of psychiatric symptoms and social and global functioning were included.

RESULTS: A total of 119 youths were enrolled. The mean age at illness onset was 11.1 +/- 3.5 years. Patients with SZ and schizoaffective disorder had similar ratings on the Positive and Negative Symptom Scale, Brief Psychiatric Rating Scale for Children, and Clinical Global Impression-Severity Scale. The overall level of functioning was similar in the two groups. A comparison to published reports of adults with SZ indicates that these youths may have more severe symptoms based on results of the Positive and Negative Symptom Scale.

CONCLUSIONS: This is one of the largest samples of youths with SZ spectrum disorders studied to date and the largest assessment of youths with schizoaffective disorder. High rates of symptoms and general psychopathology were noted. There was a substantial degree of social and functional impairment. The symptom profiles are consistent with, but more severe than, those reported in the adult literature.

DOI of Published Version

10.1097/chi.0b013e31807083fd

Source

J Am Acad Child Adolesc Psychiatry. 2007 Aug;46(8):979-88. Link to article on publisher's site

Journal/Book/Conference Title

Journal of the American Academy of Child and Adolescent Psychiatry

Related Resources

Link to Article in PubMed

PubMed ID

17667477

Repository Citation

Frazier JA, McClellan J, Findling RL, Vitiello B, Anderson R, Zablotsky B, Williams E, McNamara NK, Jackson JA, Ritz L, Hlastala SA, Pierson L, Varley JA, Puglia M, Maloney AE, Ambler D, Hunt-Harrison T, Hamer RM, Noyes N, Lieberman JA, Sikich L. (2007). Treatment of early-onset schizophrenia spectrum disorders (TEOSS): demographic and clinical characteristics. Psychiatry Publications. https://doi.org/10.1097/chi.0b013e31807083fd. Retrieved from https://escholarship.umassmed.edu/psych_pp/410