eScholarship@UMMS

Title

Cortical gray matter differences identified by structural magnetic resonance imaging in pediatric bipolar disorder

Authors

Jean A. Frazier, University of Massachusetts Medical SchoolFollow
Janis L. Breeze, McLean Hospital
Nikos Makris, Massachusetts General Hospital
Anthony J. Giuliano, Harvard Medical School
Martha R. Herbert, Massachusetts General Hospital
Larry J. Seidman, Harvard Medical School
Joseph Biederman, Harvard Medical School
Steven M. Hodge, University of Massachusetts Medical SchoolFollow
Megan E. Dieterich, Harvard Medical School
Emily D. Gerstein, Harvard Medical School
David N. Kennedy, University of Massachusetts Medical SchoolFollow
Scott L. Rauch, Harvard Medical School
Bruce M. Cohen, McLean Hospital
Verne S. Caviness Jr., Massachusetts General Hospital

UMMS Affiliation

Department of Psychiatry

Publication Date

2005-12-13

Document Type

Article

Subjects

Adolescent; Bipolar Disorder; Brain Mapping; Case-Control Studies; Cerebral Cortex; Child; Female; Functional Laterality; Humans; Imaging, Three-Dimensional; *Magnetic Resonance Imaging; Male; Multivariate Analysis; Regression Analysis

Disciplines

Psychiatry

Abstract

OBJECTIVE: Few magnetic resonance imaging (MRI) studies of bipolar disorder (BPD) have investigated the entire cerebral cortex. Cortical gray matter (GM) volume deficits have been reported in some studies of adults with BPD; this study assessed the presence of such deficits in children with BPD.

METHODS: Thirty-two youths with DSM-IV BPD (mean age 11.2 +/- 2.8 years) and 15 healthy controls (HC) (11.2 +/- 3.0 years) had structured and clinical interviews, neurological examinations, neurocognitive testing, and MRI scanning on a 1.5 T GE Scanner. Image parcellation divided the neocortex into 48 gyral-based units per hemisphere, and these units were combined into frontal (FL), temporal (TL), parietal (PL), and occipital (OL) lobe volumes. Volumetric differences were examined using univariate linear regression models with alpha = 0.05.

RESULTS: Relative to controls, the BPD youth had significantly smaller bilateral PL, and left TL. Analysis of PL and TL gyri showed significantly smaller volume in bilateral postcentral gyrus, and in left superior temporal and fusiform gyri, while the parahippocampal gyri were bilaterally increased in the BPD group. Although the FL overall did not differ between groups, an exploratory analysis showed that the right middle frontal gyrus was also significantly smaller in the BPD group.

CONCLUSIONS: Children with BPD showed deficits in PL and TL cortical GM. Further analyses of the PL and TL found differences in areas involved in attentional control, facial recognition, and verbal and declarative memory. These cortical deficits may reflect early age of illness onset.

DOI of Published Version

10.1111/j.1399-5618.2005.00258.x

Source

Bipolar Disord. 2005 Dec;7(6):555-69. Link to article on publisher's site

Journal/Book/Conference Title

Bipolar disorders

Related Resources

Link to Article in PubMed

PubMed ID

16403181

Repository Citation

Frazier JA, Breeze JL, Makris N, Giuliano AJ, Herbert MR, Seidman LJ, Biederman J, Hodge SM, Dieterich ME, Gerstein ED, Kennedy DN, Rauch SL, Cohen BM, Caviness VS. (2005). Cortical gray matter differences identified by structural magnetic resonance imaging in pediatric bipolar disorder. Psychiatry Publications and Presentations. https://doi.org/10.1111/j.1399-5618.2005.00258.x. Retrieved from https://escholarship.umassmed.edu/psych_pp/401