Title
Quantitative magnetic resonance imaging of the corpus callosum in childhood onset schizophrenia
UMMS Affiliation
Department of Psychiatry
Publication Date
1997-02-07
Document Type
Article
Subjects
Adolescent; Age of Onset; Child; Corpus Callosum; Female; Humans; *Magnetic Resonance Imaging; Male; Schizophrenia
Disciplines
Psychiatry
Abstract
Corpus callosum size has been found to be abnormal in adult schizophrenia, and other studies have implicated abnormal interhemispheric communication in this disorder. To assess continuity with brain abnormalities in the later onset disorder and to further localize brain maldevelopment, this structure was examined in a unique sample of childhood onset schizophrenics. Anatomic brain magnetic resonance imaging scans were acquired for 25 patients (mean age 13.9 +/- 2.1) who had onset of schizophrenia by age 12 (mean age at onset 9.9 +/- 1.9) and 55 normal children. The midsagittal area of the corpus callosum was divided into seven sections. With no adjustment for brain volume, no diagnostic differences were observed. After adjustment for the smaller cerebral volume of the schizophrenics, larger total, anterior and posterior corpus callosum areas emerged for the schizophrenics. These findings provide further evidence for continuity between childhood onset and later onset schizophrenia and support other studies showing white matter sparing in the context of decreased cortical volume.
Source
Psychiatry Res. 1997 Feb 7;68(2-3):77-86.
Journal/Book/Conference Title
Psychiatry research
Related Resources
PubMed ID
9104755
Repository Citation
Jacobsen LK, Giedd JN, Rajapakse JC, Hamburger SD, Vaituzis AC, Frazier JA, Lenane MC, Rapoport JL. (1997). Quantitative magnetic resonance imaging of the corpus callosum in childhood onset schizophrenia. Psychiatry Publications and Presentations. Retrieved from https://escholarship.umassmed.edu/psych_pp/372