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Authors
Zhang, NanyinRane, Pallavi
Huang, Wei
Liang, Zhifeng
Kennedy, David
Frazier, Jean A.
King, Jean A.
UMass Chan Affiliations
Department of PsychiatryDocument Type
Journal ArticlePublication Date
2010-04-13Keywords
AnimalsBrain
Brain Mapping
Cerebral Cortex
Cerebrovascular Circulation
Consciousness
Feasibility Studies
Imaging, Three-Dimensional
Magnetic Resonance Imaging
Male
Neural Pathways
Oxygen
Prefrontal Cortex
Rats
Rats, Long-Evans
Reproducibility of Results
Rest
Signal Processing, Computer-Assisted
Thalamus
Wakefulness
Psychiatry
Metadata
Show full item recordAbstract
In the present study we mapped brain functional connectivity in the conscious rat at the "resting state" based on intrinsic blood-oxygenation-level dependent (BOLD) fluctuations. The conscious condition eliminated potential confounding effects of anesthetic agents on the connectivity between brain regions. Indeed, using correlational analysis we identified multiple cortical and subcortical regions that demonstrated temporally synchronous variation with anatomically well-defined regions that are crucial to cognitive and emotional information processing including the prefrontal cortex (PFC), thalamus and retrosplenial cortex. The functional connectivity maps created were stringently validated by controlling for false positive detection of correlation, the physiologic basis of the signal source, as well as quantitatively evaluating the reproducibility of maps. Taken together, the present study has demonstrated the feasibility of assessing functional connectivity in conscious animals using fMRI and thus provided a convenient and non-invasive tool to systematically investigate the connectional architecture of selected brain networks in multiple animal models.Source
J Neurosci Methods. 2010 Jun 15;189(2):186-96. Epub 2010 Apr 9. Link to article on publisher's siteDOI
10.1016/j.jneumeth.2010.04.001Permanent Link to this Item
http://hdl.handle.net/20.500.14038/45829PubMed ID
20382183Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.jneumeth.2010.04.001