Procedure for minimizing stress for fMRI studies in conscious rats
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Authors
King, Jean A.Garelick, Timothy S.
Brevard, Mathew E.
Chen, Wei
Messenger, Tara L.
Duong, Timothy Q.
Ferris, Craig F.
UMass Chan Affiliations
Department of PsychiatryDocument Type
Journal ArticlePublication Date
2005-06-21Keywords
AcclimatizationAdaptation, Psychological
Animals
Blood Pressure
Brain
Cerebrovascular Circulation
Corticosterone
Hypothalamo-Hypophyseal System
Magnetic Resonance Imaging
Male
Rats
Rats, Sprague-Dawley
Stress, Psychological
Psychiatry
Metadata
Show full item recordAbstract
Functional magnetic resonance imaging (fMRI) in conscious animals is evolving as a critical tool for neuroscientists. The present study explored the effectiveness of an acclimation procedure in minimizing the stress experienced by the animal as assessed by alterations in physiological parameters including heart rate, respiratory rate, and serum corticosterone levels. Results confirm that as the stress of the protocol is minimized, there is a significant decrease in head movements and enhancement in data quality. The feasibility of improving the quality of fMRI data acquired in alert rats by utilizing a relatively simple technique is presented.Source
J Neurosci Methods. 2005 Oct 30;148(2):154-60. Epub 2005 Jun 16. Link to article on publisher's siteDOI
10.1016/j.jneumeth.2005.04.011Permanent Link to this Item
http://hdl.handle.net/20.500.14038/45822PubMed ID
15964078Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.jneumeth.2005.04.011