Mania after withdrawal of isocarboxazid
Department of Psychiatry
Adult; Bipolar Disorder; Dopamine; Female; Humans; Isocarboxazid; Male; *Substance Withdrawal Syndrome
Two cases of mania following the discontinuation of treatment with isocarboxazid are described. Although this phenomenon has been reported by several investigators to occur after cessation of tricyclic antidepressant therapy, there exists only one isolated report of hypomania after discontinuation of monoamine oxidase inhibitors. Possible mechanisms for the occurrence of hypomania and mania after withdrawal from antidepressants are discussed.
J Clin Psychopharmacol. 1985 Dec;5(6):340-2.
Journal of clinical psychopharmacology
Rothschild, Anthony J., "Mania after withdrawal of isocarboxazid" (1985). Psychiatry Publications and Presentations. 23.