Toward a biochemical classification of depressive disorders IX. DST results and platelet MAO activity
Department of Psychiatry
Adult; Age Factors; Aged; Blood Platelets; Depressive Disorder; Dexamethasone; Female; Humans; Hydrocortisone; Male; Middle Aged; Monoamine Oxidase
Post-dexamethasone cortisol and platelet monoamine oxidase (MAO) activity levels were examined in 50 depressed patients. The incidence of non-suppression was significantly greater in patients with high platelet MAO activity than in those with low activity. Similar results were obtained when males and females were analysed separately. The mean 4 p.m. post-dexamethasone cortisol level was significantly higher in those patients who had high MAO activity than in their low MAO counterparts. Moreover, a statistically significant positive correlation was observed between platelet MAO activity and 4 p.m. post-dexamethasone cortisol levels.
Br J Psychiatry. 1985 Jun;146:633-7.
The British journal of psychiatry : the journal of mental science
Schatzberg AF, Rothschild AJ, Gerson B, Lerbinger JE, Schildkraut JJ. (1985). Toward a biochemical classification of depressive disorders IX. DST results and platelet MAO activity. Psychiatry Publications. Retrieved from https://escholarship.umassmed.edu/psych_pp/20