A double-blind placebo-controlled pilot study of risperidone for decreasing cue-elicited craving in recently withdrawn cocaine dependent patients
Department of Psychiatry
Adult; Analysis of Variance; Behavior, Addictive; Cocaine-Related Disorders; Cues; Dopamine Antagonists; Double-Blind Method; Humans; New Jersey; Pilot Projects; Risperidone; Serotonin Antagonists
Cocaine use causes an initial increase in dopamine and serotonin neurotransmission that is largely responsible for the pleasurable and reinforcing effects of the drug. Dysregulation of these neurotransmitters during withdrawal plays an important role in craving. Recent research has focused on the use of dopamine and serotonin antagonists early in recovery to reduce cocaine craving in both schizophrenic and non-schizophrenic cocaine dependent patients. This 2-week, double blind, placebo-controlled study compared risperidone vs. placebo in reducing cue-elicited cocaine craving. Thirty-four subjects with cocaine dependence were randomized to either risperidone or a placebo and underwent a weekly cue-exposure procedure. Although both groups had a reduction in craving over time, there were no significant differences among those treated with risperidone (n=19) compared to those taking a placebo (n=16) on the four craving dimensions. The results do not support the hypothesis that risperidone reduces cocaine craving among non-schizophrenic cocaine-dependent individuals.
DOI of Published Version
J Subst Abuse Treat. 2004 Jul;27(1):45-9. Link to article on publisher's site
Journal of substance abuse treatment
Smelson DA, Williams J, Ziedonis DM, Sussner BD, Losonczy MF, Engelhart C, Kaune M. (2004). A double-blind placebo-controlled pilot study of risperidone for decreasing cue-elicited craving in recently withdrawn cocaine dependent patients. Psychiatry Publications and Presentations. https://doi.org/10.1016/j.jsat.2004.03.009. Retrieved from https://escholarship.umassmed.edu/psych_pp/195