Title
Risperidone decreases craving and relapses in individuals with schizophrenia and cocaine dependence
UMMS Affiliation
Department of Veterans Affairs
Publication Date
2002-10-03
Document Type
Article
Subjects
Adult; Antipsychotic Agents; Cocaine-Related Disorders; Comorbidity; Female; Humans; Male; Middle Aged; Motivation; Pilot Projects; Psychiatric Status Rating Scales; Recurrence; Risperidone; Schizophrenia; *Schizophrenic Psychology; Substance Withdrawal Syndrome
Disciplines
Psychiatry
Abstract
OBJECTIVE: To examine the efficacy of atypical neuroleptics for decreasing craving and drug relapses during protracted withdrawal in individuals dually diagnosed with schizophrenia and cocaine dependence.
METHOD: We conducted a 6-week, open-label pilot study comparing risperidone with typical neuroleptics in a sample of withdrawn cocaine-dependent schizophrenia patients.
RESULTS: Preliminary results suggest that individuals treated with risperidone had significantly less cue-elicited craving and substance abuse relapses at study completion. Further, they showed a trend toward a greater reduction in negative and global symptoms of schizophrenia.
CONCLUSION: Atypical neuroleptics may help reduce craving and relapses in this population. Future research should include more rigorous double-blind placebo-controlled studies with this class of medications.
Source
Can J Psychiatry. 2002 Sep;47(7):671-5.
Journal/Book/Conference Title
Canadian journal of psychiatry. Revue canadienne de psychiatrie
Related Resources
PubMed ID
12355680
Repository Citation
Smelson DA, Losonczy MF, Davis CW, Kaune M, Williams J, Ziedonis DM. (2002). Risperidone decreases craving and relapses in individuals with schizophrenia and cocaine dependence. Psychiatry Publications. Retrieved from https://escholarship.umassmed.edu/psych_pp/183