Risperidone decreases craving and relapses in individuals with schizophrenia and cocaine dependence
Department of Veterans Affairs
Adult; Antipsychotic Agents; Cocaine-Related Disorders; Comorbidity; Female; Humans; Male; Middle Aged; Motivation; Pilot Projects; Psychiatric Status Rating Scales; Recurrence; Risperidone; Schizophrenia; *Schizophrenic Psychology; Substance Withdrawal Syndrome
OBJECTIVE: To examine the efficacy of atypical neuroleptics for decreasing craving and drug relapses during protracted withdrawal in individuals dually diagnosed with schizophrenia and cocaine dependence.
METHOD: We conducted a 6-week, open-label pilot study comparing risperidone with typical neuroleptics in a sample of withdrawn cocaine-dependent schizophrenia patients.
RESULTS: Preliminary results suggest that individuals treated with risperidone had significantly less cue-elicited craving and substance abuse relapses at study completion. Further, they showed a trend toward a greater reduction in negative and global symptoms of schizophrenia.
CONCLUSION: Atypical neuroleptics may help reduce craving and relapses in this population. Future research should include more rigorous double-blind placebo-controlled studies with this class of medications.
Can J Psychiatry. 2002 Sep;47(7):671-5.
Canadian journal of psychiatry. Revue canadienne de psychiatrie
Smelson DA, Losonczy MF, Davis CW, Kaune M, Williams J, Ziedonis DM. (2002). Risperidone decreases craving and relapses in individuals with schizophrenia and cocaine dependence. Psychiatry Publications. Retrieved from https://escholarship.umassmed.edu/psych_pp/183