Effects of clozapine on smoking in chronic schizophrenic outpatients
Department of Psychiatry
Medical Subject Headings
Adult; *Ambulatory Care; Antipsychotic Agents; Chronic Disease; Clozapine; Coffee; Drinking; Female; Humans; Male; Middle Aged; Pilot Projects; Prevalence; Psychiatric Status Rating Scales; Psychotic Disorders; Retrospective Studies; Schizophrenia; Smoking; Smoking Cessation
BACKGROUND: The effects of clozapine administration on smoking were examined in chronic schizophrenic outpatients.
METHOD: Twenty-nine of 30 schizophrenic outpatients enrolled in a university-affiliated Community Mental Health Center clozapine clinic were retrospectively surveyed by semistructured questionnaire regarding smoking before and after clozapine administration.
RESULTS: Smokers comprised 62% (N = 18) of patients, and within this group, there was a significant decrease in reported daily cigarette use during clozapine treatment compared with level of use when patients had been treated with typical neuroleptics (1.67 +/- 1.13 vs. 1.26 +/- 0.72 packs/day, p = .025).
CONCLUSION: Clozapine may alter smoking behaviors in chronic schizophrenics.
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Citation: J Clin Psychiatry. 1995 Aug;56(8):344-6.
George, Tony P.; Sernyak, Michael J.; Ziedonis, Douglas M.; and Woods, Scott W., "Effects of clozapine on smoking in chronic schizophrenic outpatients" (1995). Psychiatry Publications and Presentations. 166.
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