The dexamethasone suppression test: identification of subtypes of depression
Department of Psychiatry
Adolescent; Adult; Aged; Bipolar Disorder; Depressive Disorder; Dexamethasone; Diagnosis, Differential; Female; Humans; Hydrocortisone; Male; Middle Aged
In this study mean 4 p.m. cortisol levels were significantly higher in patients with major depression than in control subjects or in patients with bipolar depression or dysthymic-related disorders. Moreover, the distribution of values differed significantly among groups. Eighteen of 45 patients with major depression had cortisol levels of 10 micrograms/dl or more, compared with 2 of 20 bipolar depressed patients and 0 of 31 controls. Patients with very high cortisol levels (15 micrograms/dl or more) tended to fulfill criteria for major depression with mood-congruent psychosis. The distribution of values in the major depression group also suggested the existence of three major subgroups. The authors discuss the implications of these data.
Am J Psychiatry. 1983 Jan;140(1):88-91.
The American journal of psychiatry
Schatzberg AF, Rothschild AJ, Stahl JB, Bond TC, Rosenbaum AH, Lofgren SB, MacLaughlin RA, Sullivan MA, Cole JO. (1983). The dexamethasone suppression test: identification of subtypes of depression. Psychiatry Publications and Presentations. Retrieved from https://escholarship.umassmed.edu/psych_pp/12