A splitting brain: Imbalanced neural networks in schizophrenia

UMMS Affiliation

Department of Psychiatry; Systems and Psychosocial Advances Research Center

Publication Date


Document Type



Adolescent; Adult; Brain; Brain Mapping; Female; Humans; Magnetic Resonance Imaging; Male; Nerve Net; Schizophrenia; Young Adult


Mental Disorders | Neuroscience and Neurobiology | Psychiatric and Mental Health | Psychiatry


Dysconnectivity between key brain systems has been hypothesized to underlie the pathophysiology of schizophrenia. The present study examined the pattern of functional dysconnectivity across whole-brain neural networks in 121 first-episode, treatment-naive patients with schizophrenia by using resting-state functional magnetic resonance imaging (rsfMRI). Group independent component analysis (ICA) was first applied to rsfMRI data to extract 90 functional components of the brain. The functional connectivity between these ICA components was then evaluated and compared between the patient and control groups. To examine the functional roles of significantly altered between-component connections in patients, each ICA component was ascribed to one of 10 previously well-defined brain networks/areas. Relative to findings in healthy controls (n=103), 29 altered functional connections including 19 connections with increased connectivity and 10 connections with decreased connectivity in schizophrenia patients were found. Increased connectivity was mainly within the default mode network (DMN) and between the DMN and cognitive networks, whereas decreased connectivity was predominantly associated with sensory networks. Given the key roles of the DMN in internal mental processes and sensory networks in inputs from the external environment, these patterns of altered brain network connectivity could suggest imbalanced neural processing of internal and external information in schizophrenia.


Functional connectivity, Neural networks, Resting state, Schizophrenia, fMRI

DOI of Published Version



Psychiatry Res. 2015 May 30;232(2):145-53. doi: 10.1016/j.pscychresns.2015.03.001. Epub 2015 Mar 11. Link to article on publisher's site

Journal/Book/Conference Title

Psychiatry research

Related Resources

Link to Article in PubMed

PubMed ID