Neural correlates of impulsivity factors in psychiatric patients and healthy volunteers: a voxel-based morphometry study
UMass Chan Affiliations
Department of Psychiatry, Center for Mental Health Services ResearchDocument Type
Journal ArticlePublication Date
2011-03-01Keywords
AdultBrain
Cerebellum
Cerebral Cortex
Data Interpretation, Statistical
Female
Functional Laterality
Humans
Image Processing, Computer-Assisted
Impulsive Behavior
Magnetic Resonance Imaging
Male
Prefrontal Cortex
Health Services Research
Mental and Social Health
Neuroscience and Neurobiology
Psychiatric and Mental Health
Psychiatry
Psychiatry and Psychology
Metadata
Show full item recordAbstract
According to bottom-up/top-down models, impulsivity facets are represented across the cerebral cortex and subcortex. Hypothesized gray matter correlates of motor, attentional and non-planning impulsivity were examined in groups of 35 psychiatric patients characterized by self-control problems and 18 healthy volunteers. Among patients, a positive correlation was found between motor impulsivity and the right cerebellum, and a negative correlation emerged between attentional impulsivity and the left lateral orbitofrontal cortex (OFC). Among controls, attentional and motor impulsivity correlated negatively with the left superior temporal gyrus, while non-planning impulsivity correlated positively with the left OFC and lateral frontopolar cortex. Follow-up analyses revealed convergence in correlation patterns from patients to controls, but not vice versa. That pattern suggested broader neural representation of the trait in the healthy controls, who were less impulsive than the psychiatric patients.Source
Brain Imaging Behav. 2011 Mar;5(1):52-64. Link to article on publisher's websiteDOI
10.1007/s11682-010-9112-1Permanent Link to this Item
http://hdl.handle.net/20.500.14038/45367PubMed ID
21210255Related Resources
Link to article in PubMedae974a485f413a2113503eed53cd6c53
10.1007/s11682-010-9112-1