New directions in the treatment of anxiety disorders

UMMS Affiliation

Department of Psychiatry



Document Type


Medical Subject Headings

Anxiety Disorders


Behavioral Disciplines and Activities | Mental and Social Health | Pharmaceutics and Drug Design | Psychiatry | Psychiatry and Psychology


Anxiety disorders play a prominent role in general medical and psychiatric practice, and their lack of recognition leads to significant morbidity. A major thrust of recent patent activity builds on clinical successes provided by serotonergic and GABA-ergic agents. A new understanding of the molecular basis for GABAA receptor subtype selectivity presents new possibilities for designing drugs that are highly specific for subpopulations of this receptor family. Despite a lack of clinical experience with less well-known neuropeptide agents, corticotrophin-releasing hormone (CRH) antagonists appear promising. This paper reviews the most prevalent anxiety disorders, their pharmacological treatments and describes trends in therapeutic patent activity since 1997.

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Citation: Bain EE, Candilis P. “New directions in the treatment of anxiety disorders.” Expert Opinion on Therapeutic Patents, 10(4): 389-402, 2000.