Hypothalamic lesions and intermittent explosive disorder
Department of Psychiatry
Adult; Aggression; Craniopharyngioma; Delirium, Dementia, Amnestic, Cognitive; Disorders; Female; Follow-Up Studies; Humans; Hypothalamo-Hypophyseal System; Magnetic Resonance Imaging; Male; Neurologic Examination; Neuropsychological Tests; Pituitary Neoplasms; *Violence
Health Services Research | Mental and Social Health | Psychiatric and Mental Health | Psychiatry | Psychiatry and Psychology
The authors present two cases of patients with craniopharyngiomas who meet the DSM-III-R criteria for intermittent explosive disorder. Episodes of rage developed before and/or after surgery for removal of the craniopharyngioma. Magnetic resonance imaging revealed hypothalamic-hypophyseal involvement. It is suggested that hypothalamic lesions played a major role in the development of aggressive behavior in both cases.
J Neuropsychiatry Clin Neurosci. 1992 Winter;4(1):45-50.
The Journal of neuropsychiatry and clinical neurosciences
Tonkonogy, Joseph M. and Geller, Jeffrey L., "Hypothalamic lesions and intermittent explosive disorder" (1992). Implementation Science and Practice Advances Research Center Publications. 164.