UMMS Affiliation

Department of Psychiatry

Publication Date


Document Type



Beneficence; *Clinical Trials as Topic; *Cognition; *Decision Making; Disclosure; Goals; *Human Experimentation; Humans; *Informed Consent; Patient Care; Patient Participation; Patient Satisfaction; Research


Health Services Research | Mental and Social Health | Psychiatric and Mental Health | Psychiatry | Psychiatry and Psychology


Summary Points:

A key component of informed consent to participate in medical research is the understanding that research is not the same as treatment.

However, studies have found that some research participants do not appreciate important differences between research and treatment, a phenomenon called “therapeutic misconception.”

A consistent definition of therapeutic misconception is missing from the literature, and this hinders attempts to define its prevalence or ways to reduce it.

This paper proposes a new definition and describes how it can be operationalized.

DOI of Published Version



PLoS Med. 2007 Nov 27;4(11):e324. Link to article on publisher's site

Journal/Book/Conference Title

PLoS medicine

Related Resources

Link to Article in PubMed

PubMed ID




To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.