Title

Fluoxetine, smoking, and history of major depression: A randomized controlled trial

UMMS Affiliation

Department of Medicine, Division of Preventive and Behavioral Medicine

Publication Date

2007-02-14

Document Type

Article

Subjects

Adolescent; Adult; *Depressive Disorder, Major; Fluoxetine; Follow-Up Studies; Humans; Middle Aged; Questionnaires; Serotonin Uptake Inhibitors; Smoking

Disciplines

Behavioral Disciplines and Activities | Behavior and Behavior Mechanisms | Community Health and Preventive Medicine | Preventive Medicine

Abstract

The study was a randomized placebo-controlled trial testing whether fluoxetine selectively enhances cessation for smokers with a history of depression. Euthymic smokers with (H+, n = 109) or without (H-, n = 138) a history of major depression received 60 mg fluoxetine or placebo plus group behavioral quit-smoking treatment for 12 weeks. Fluoxetine initially enhanced cessation for H+ smokers (p = .02) but subsequently impaired cessation regardless of depressive history. Six months after quit date, fluoxetine-treated participants were 3.3 times more likely to be smoking (p = .02). Further research is warranted to determine why high-dose fluoxetine produces continuing effects that oppose tobacco abstinence.

DOI of Published Version

10.1037/0022-006X.75.1.85

Source

J Consult Clin Psychol. 2007 Feb;75(1):85-94. Link to article on publisher's site

Journal/Book/Conference Title

Journal of consulting and clinical psychology

Related Resources

Link to Article in PubMed

PubMed ID

17295567

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