Fluoxetine, smoking, and history of major depression: A randomized controlled trial

UMMS Affiliation

Department of Medicine, Division of Preventive and Behavioral Medicine



Document Type



Adolescent; Adult; *Depressive Disorder, Major; Fluoxetine; Follow-Up Studies; Humans; Middle Aged; Questionnaires; Serotonin Uptake Inhibitors; Smoking


Behavioral Disciplines and Activities | Behavior and Behavior Mechanisms | Community Health and Preventive Medicine | Preventive Medicine


The study was a randomized placebo-controlled trial testing whether fluoxetine selectively enhances cessation for smokers with a history of depression. Euthymic smokers with (H+, n = 109) or without (H-, n = 138) a history of major depression received 60 mg fluoxetine or placebo plus group behavioral quit-smoking treatment for 12 weeks. Fluoxetine initially enhanced cessation for H+ smokers (p = .02) but subsequently impaired cessation regardless of depressive history. Six months after quit date, fluoxetine-treated participants were 3.3 times more likely to be smoking (p = .02). Further research is warranted to determine why high-dose fluoxetine produces continuing effects that oppose tobacco abstinence.

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Citation: J Consult Clin Psychol. 2007 Feb;75(1):85-94. Link to article on publisher's site

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