A new dietary inflammatory index predicts interval changes in serum high-sensitivity C-reactive protein

UMMS Affiliation

Department of Medicine, Division of Cardiovascular Medicine; Clinical and Population Health Research Program; Department of Medicine, Division of Preventive and Behavioral Medicine

Publication Date


Document Type



Adult; Biological Markers; C-Reactive Protein; Diet; Energy Intake; Exercise; Female; Homeostasis; Humans; Inflammation; Interleukin-1; Interleukin-10; Interleukin-4; Interleukin-6; Interviews as Topic; Male; Middle Aged; Reference Values; Search Engine; Sensitivity and Specificity; Tumor Necrosis Factor-alpha


Behavioral Disciplines and Activities | Behavior and Behavior Mechanisms | Community Health and Preventive Medicine | Preventive Medicine


Inflammation is associated with a number of chronic conditions, such as cancer and cardiovascular disease. Reducing inflammation may help prevent or treat these conditions. Diet has consistently been shown to modulate inflammation. To facilitate research into the inflammatory effect of diet on health in humans, we sought to develop and validate an Inflammatory Index designed to assess the inflammatory potential of individuals' diets. An Inflammatory Index was developed based on the results of an extensive literature search. Using data from a longitudinal observational study that carefully measured diet and the inflammatory marker, serum high-sensitivity (hs) C-reactive protein (CRP), in approximately 600 adults for 1 y, we conducted analyses to test the effect of Inflammatory Index score on hs-CRP as a continuous and dichotomous (3 mg/L) indicator of inflammatory response, while controlling for important potential confounders. Results based on continuous measures of hs-CRP suggested that an increasing Inflammatory Index score (representing movement toward an antiinflammatory diet) was associated with a decrease in hs-CRP. Analyses using hs-CRP as a dichotomous variable showed that an antiinflammatory diet was associated with a decrease in the odds of an elevated hs-CRP (P = 0.049). The results are consistent with the ability of the Inflammatory Index to predict hs-CRP and provide additional evidence that diet plays a role in the regulation of inflammation, even after careful control of a wide variety of potential confounders.

DOI of Published Version



J Nutr. 2009 Dec;139(12):2365-72. Epub 2009 Oct 28. Link to article on publisher's site

Journal/Book/Conference Title

The Journal of nutrition

Related Resources

Link to Article in PubMed

PubMed ID